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Chemical Compound Review

Ono-NT-126     (Z)-6-[(1S,4S,5S,6S)-6-[[(4...

Synonyms: Ono-NT 126, AC1O5RE8, 130466-54-5
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Disease relevance of Ono-NT-126


High impact information on Ono-NT-126

  • In this study, we developed a guinea pig model for propranolol-induced bronchoconstriction (PIB) after antigen inhalation and investigated the effect of specific thromboxane (TXA2) receptor antagonists, S-1452 and ONO NT-126, on PIB in passively sensitized and artificially ventilated guinea pigs to determine whether TXA2 is involved in PIB [3].
  • 2. The effects of inhaled IL-8 on bronchial responsiveness and of the TXA2 antagonists, S-1452 (0.01 and 0.1 mg kg-1) and ONO-NT-126 (1.0 or 10 micrograms kg-1), on IL-8-induced BHR were examined by use of a modified Konzett-Rössler method in guinea-pigs [4].
  • Treatment with specific TXA2 antagonist, calcium 5(Z)-1R,2S,3S,4S-7-[3-phenylsulfonylaminobicyclo[2,2,1]hept-2-yl]- 5-heptonoate hydrate (S-1452) and 5(Z-6-[(1R,2R,3R,4S)-3-(N-4-bromobenzenesulfonyl aminomethyl) bicyclo[2,2,1]heptane-2-yl]-hex-5-enoic acid (ONO-NT-126), enhanced the cisplatin-induced apoptosis in each cell line [5].
  • [3H]SQ29548 binding to membranes was inhibited by ONO NT-126 and the other TXA2 antagonists with Ki values (nM) of 0.09, 2.18, 8.35 and 25.9 for ONO NT-126, S-145, SQ29548 and ONO3708, respectively [1].


  1. ONO NT-126 is a potent and selective thromboxane A2 antagonist in human astrocytoma cells. Nakahata, N., Sato, K., Abe, M.T., Nakanishi, H. Eur. J. Pharmacol. (1990) [Pubmed]
  2. Effects of a thromboxane A2 receptor antagonist in an animal model of inflammatory bowel disease. Taniguchi, T., Tsukada, H., Nakamura, H., Kodama, M., Fukuda, K., Tominaga, M., Seino, Y. Digestion (1997) [Pubmed]
  3. Involvement of thromboxane A2 in propranolol-induced bronchoconstriction after allergic bronchoconstriction in guinea pigs. Songür, N., Fujimura, M., Mizuhashi, K., Saito, M., Xiu, Q.Y., Matsuda, T. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  4. Effect of thromboxane A2 antagonists on bronchial hyperresponsiveness induced immediately after interleukin-8 inhalation in guinea-pigs. Fujimura, M., Myou, S., Nomura, M., Matsuda, T., Harada, A., Mukaida, N., Matsushima, K., Nonomura, A. Br. J. Pharmacol. (1997) [Pubmed]
  5. Up-regulation of ICH-1L protein by thromboxane A2 antagonists enhances cisplatin-induced apoptosis in non-small-cell lung-cancer cell lines. Fujimura, M., Kasahara, K., Shirasaki, H., Heki, U., Iwasa, K., Ueda, A., Matsuda, T. J. Cancer Res. Clin. Oncol. (1999) [Pubmed]
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