Disease relevance of Peroxynitrite

• 4. The PN scavenger uric acid (100-250 mg x kg(-1) i.p. four times daily) given prophylactically until the end of the experiment (day 14), in a dose compatible with its PN scavenging activity, significantly decreased both the synovitis and the GAG loss [1].

High impact information on Peroxynitrite

• Incubation of SNP or peroxynitrite (PN; 0.01-1 mM) with CYP4A recombinant membranes caused a concentration-dependent inhibition of 20-HETE synthesis, with both chemicals having a greater inhibitory effect on CYP4A3-catalyzed activity [2].
• NOS inhibitors and a PN scavenger were able to reduce the cellular infiltration, while displaying opposite effects on cartilage homeostasis either by enhancing or ameliorating the damage, respectively [1].
• The purpose of this study is to determine whether the NO donor S-nitroso-N-acetylpenicillamine (SNAP) and PN can degrade chondroitin sulfates in vitro [3].
• SNAP treatment partially degraded CSB and CSC, whereas PN partially degraded all three chondroitin sulfates [3].
• The combined radiative and thermal perturbations on the concentrations of O, O(1 D), OH, HO2, H2O2, NO, NO2, NO3, N2O5, HNO3, HO2NO2, Cl, ClO, ClO2, HOCl, ClNO3, and HCl are computed and presented in detail [4].

Gene context of Peroxynitrite

• The NO donor SNAP (2 mM, pH 4.0) or PN (5 mM, pH 7.4) was incubated for at least 1 week at 37 degrees C with CSA, CSB, or CSC [3].

References