The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

TMSCl     chloro-trimethyl-silane

Synonyms: TMCS, Silane M3, CCRIS 790, C72854_ALDRICH, AG-H-02080, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on chloro-trimethyl-silane


Biological context of chloro-trimethyl-silane


Anatomical context of chloro-trimethyl-silane

  • Despite the efficient guidance at low approach angles, nanosized (<700 nm wide) TMCS tracks surrounded by SiO(2) were not effective in guiding actin filaments [9].

Associations of chloro-trimethyl-silane with other chemical compounds

  • Methodological studies showed that the alcoholysis using trimethylchlorosilane/methanol (1:9, v/v) is an excellent method for the complete transesterification of lipids and quantitative formation of methyl esters [10].
  • Spectrophotometric analysis of HMM depletion during incubation, K/EDTA ATPase measurements, and total internal reflection fluorescence spectroscopy of HMM binding showed only minor differences in HMM surface densities between TMCS and SiO(2)/glass [4].
  • Successful separation of five species of bacteria was obtained using a trimethylchlorosilane-modified capillary and a divinylbenzene-modified with suppressed EOF over a short distance (8.5 cm) [11].
  • The urine samples were extracted using ethyl acetate, evaporated and derivatized with N, O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) with 1% trimethylchlorosilane (TMCS), and analyzed by gas chromatography-mass spectrometry [12].
  • As an attempt to elucidate the factor(s) responsible for the poor performance of a copper(II)-phthalocyanine aminopropylsilica gels (CU-PCSD) column for HPLC, the silanol and/or amino groups remaining on Cu-PCSD were endcapped with trimethylchlorosilane (TMCS) or N-trimethylsilylimidazole (TMSI) [13].

Gene context of chloro-trimethyl-silane

  • 3-Methylidene-beta-lactams as potential inhibitors of beta-lactamases. Part 1: Synthesis of alpha-substituted derivatives from imines by Reformatzky reaction with chlorotrimethylsilane, silylation and Peterson olefination [14].

Analytical, diagnostic and therapeutic context of chloro-trimethyl-silane


  1. Enzymatic digestion, solid-phase extraction, and gas chromatography/mass spectrometry of derivatized intact oxazepam in urine. Langner, J.G., Gan, B.K., Liu, R.H., Baugh, L.D., Chand, P., Weng, J.L., Edwards, C., Walia, A.S. Clin. Chem. (1991) [Pubmed]
  2. Palladium-catalyzed cyclization of alkenyl beta-keto esters in the presence of chlorotrimethylsilane. Pei, T., Widenhoefer, R.A. Chem. Commun. (Camb.) (2002) [Pubmed]
  3. Electrokinetic properties of methylated quartz capillaries. Churaev, N.V., Ralston, J., Sergeeva, I.P., Sobolev, V.D. Advances in colloid and interface science. (2002) [Pubmed]
  4. Selective spatial localization of actomyosin motor function by chemical surface patterning. Sundberg, M., Balaz, M., Bunk, R., Rosengren-Holmberg, J.P., Montelius, L., Nicholls, I.A., Omling, P., Tågerud, S., Månsson, A. Langmuir : the ACS journal of surfaces and colloids. (2006) [Pubmed]
  5. New fractionation scheme for lipid classes based on "in-cell fractionation" using sequential pressurized liquid extraction. Poerschmann, J., Carlson, R. Journal of chromatography. A. (2006) [Pubmed]
  6. Mono-, di-, and tricoordinated phosphorus attached to a N-N unit: an experimental and theoretical study. Fischer, G., Herler, S., Mayer, P., Schulz, A., Villinger, A., Weigand, J.J. Inorganic chemistry. (2005) [Pubmed]
  7. Vibrational spectroscopic studies in the hydrolysis and condensation of chlorotrimethylsilane. Li, Y.S., Le, K. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2004) [Pubmed]
  8. Dealkylation of phosphonate esters with chlorotrimethylsilane. Gutierrez, A.J., Prisbe, E.J., Rohloff, J.C. Nucleosides Nucleotides Nucleic Acids (2001) [Pubmed]
  9. Actin filament guidance on a chip: toward high-throughput assays and lab-on-a-chip applications. Sundberg, M., Bunk, R., Albet-Torres, N., Kvennefors, A., Persson, F., Montelius, L., Nicholls, I.A., Ghatnekar-Nilsson, S., Omling, P., Tågerud, S., Månsson, A. Langmuir : the ACS journal of surfaces and colloids. (2006) [Pubmed]
  10. Sequential pressurized liquid extraction to determine brain-originating fatty acids in meat products as markers in bovine spongiform encephalopathy risk assessment studies. Poerschmann, J., Trommler, U., Biedermann, W., Truyen, U., Lücker, E. Journal of chromatography. A. (2006) [Pubmed]
  11. Separation of microorganisms using electromigration techniques. Szumski, M., Kłodzińska, E., Buszewski, B. Journal of chromatography. A. (2005) [Pubmed]
  12. A novel method for GHB detection in urine and its application in drug-facilitated sexual assaults. Elian, A.A. Forensic Sci. Int. (2000) [Pubmed]
  13. Effects of trimethylsilylation of copper(II)-phthalocyanine sulfonyl-aminopropyl silica gels on the separation of pi-electron-rich compounds by high-performance liquid chromatography. Iwado, A., Mifune, M., Mori, Y., Onoda, M., Kanai, T., Motohashi, N., Haginaka, J., Saito, Y. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. (2001) [Pubmed]
  14. 3-Methylidene-beta-lactams as potential inhibitors of beta-lactamases. Part 1: Synthesis of alpha-substituted derivatives from imines by Reformatzky reaction with chlorotrimethylsilane, silylation and Peterson olefination. Gürtler, S., Ruf, S., Johner, M., Otto, H.H. Die Pharmazie. (1996) [Pubmed]
  15. Preparation of thin silica films with controlled thickness and tunable refractive index. Rouse, J.H., Ferguson, G.S. J. Am. Chem. Soc. (2003) [Pubmed]
  16. Simultaneous determination of Zilpaterol and other beta agonists in calf eye by gas chromatography/tandem mass spectrometry. Bocca, B., Fiori, M., Cartoni, C., Brambilla, G. Journal of AOAC International. (2003) [Pubmed]
WikiGenes - Universities