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Chemical Compound Review:

Propiophenone 1-phenylpropan-1-one

Synonyms: Propionphenone, SureCN76464, CHEMBL193446, SureCN318818, P51605_ALDRICH, ...

Perumal, A.S. et al., Trendelenburg, U. et al., Riska, P.F. et al., Patnaik, G.K. et al., Wood, S.G. et al., et al.

Riska, Jacobs, Bloom, McKitrick, Chan,

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Disease relevance of propiophenone

Specific identification of Mycobacterium tuberculosis with the luciferase reporter mycobacteriophage: use of p-nitro-alpha-acetylamino-beta-hydroxy propiophenone [1].

High impact information on propiophenone

There was no significant effect of buropion or propiophenone on the binding of spiroperidol either in the cortex (S2 receptor) or in the limbic forebrain (dopaminergic) [2].
Studies of the pharmacokinetics and metabolism of 4-amino-propiophenone (PAPP) in rats, dogs and cynomolgus monkeys [3].
Pharmacology of 4'fluoro-3-(1-piperidyl) propiophenone (compound CN), a new centrally acting skeletal muscle relaxant [4].
Cocaine was used to inhibit neuronal uptake and COMT was blocked with 3,4-dihydroxy-2-methyl propiophenone [5].
In cat papillary muscle and nictitating membrane block of extraneuronal catechol-O-methyl transferase (COMT) by 3',4'-dihydroxy-alpha-methyl propiophenone (U-0521) or of extraneuronal uptake by hydrocortisone causes supersensitivity to catecholamines whenever the experimental conditions result in a high sensitivity of the organ to catecholamines [6].

Anatomical context of propiophenone

Though propiophenone did not have any significant effect on beta-receptors in the frontal cortex, it down-regulated beta-receptors in the limbic forebrain area significantly by 1 and 3 weeks [2].

References

Specific identification of Mycobacterium tuberculosis with the luciferase reporter mycobacteriophage: use of p-nitro-alpha-acetylamino-beta-hydroxy propiophenone. Riska, P.F., Jacobs, W.R., Bloom, B.R., McKitrick, J., Chan, J. J. Clin. Microbiol. (1997) [Pubmed]
Down regulation of beta-receptors by bupropion and its major metabolite in mouse brain. Perumal, A.S., Smith, T.M., Suckow, R.F., Cooper, T.B. Neuropharmacology (1986) [Pubmed]
Studies of the pharmacokinetics and metabolism of 4-amino-propiophenone (PAPP) in rats, dogs and cynomolgus monkeys. Wood, S.G., Fitzpatrick, K., Bright, J.E., Inns, R.H., Marrs, T.C. Human & experimental toxicology. (1991) [Pubmed]
Pharmacology of 4'fluoro-3-(1-piperidyl) propiophenone (compound CN), a new centrally acting skeletal muscle relaxant. Patnaik, G.K., Sabir, M., Dhawan, B.N. Indian J. Exp. Biol. (1979) [Pubmed]
A comparative study of the role played by some inactivation pathways in the disposition of the transmitter in the rabbit aorta and the saphenous vein of the dog. Brandão, F. Blood vessels. (1976) [Pubmed]
Supersensitivity to catecholamines after impairment of extraneuronal uptake or catechol-O-methyl transferase. Trendelenburg, U., Graefe, K.H. Fed. Proc. (1975) [Pubmed]

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