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Chemical Compound Review

spiperone     8-[4-(4-fluorophenyl)-4-oxo- butyl]-1...

Synonyms: Espiperona, Spiperonum, Spiropitan, Spiroperone, Spiroperidol, ...
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Disease relevance of spiperone


Psychiatry related information on spiperone

  • Alzheimer's disease: monoamines and spiperone binding reduced in nucleus basalis [6].
  • Additionally, the effects of chronic spiroperidol on self-stimulation of this structure may model the therapeutic effects of neuroleptics in humans [7].
  • Locomotor activity scores were significantly reduced by SCH23390, but not by spiperone [8].
  • The data was incorporated into a control system model which depicts actions of spiperone in the food-preference situation with total eating duration as the final behavioural output [9].
  • Dose-related influences of quinpirole on (a) the average latency to initiate a detection response (i.e., the S + response latency), (b) the total session duration, and (c) the number of aborted trials were also eliminated or greatly attenuated by prior spiperone injection [10].

High impact information on spiperone


Chemical compound and disease context of spiperone


Biological context of spiperone


Anatomical context of spiperone

  • The photosensitive spiperone analogue N-(p-azido-m-[125I]iodophenethyl)spiperone labeled similar sized proteins of Mr = 120,000 in membranes prepared from the kidney inner medulla, striatum, and pituitary [24].
  • In choroid plexus, however, the rank order (mianserin greater than ketanserin much greater than spiperone) and absolute potencies were consistent with binding to the 5-HT1C site [25].
  • Spiperone: evidence for uptake into secretory granules [26].
  • Spiperone at 1 microM inhibited by over 50% serotonin transport into membrane vesicles isolated from platelet dense granules; this concentration inhibited the Na+-dependent plasma membrane transport system less than 10% [26].
  • Serotonin treatment of rat uterine myometrial smooth muscle cells induced inositol phosphate (IP) turnover, which was abolished by the 5-HT(2A) receptor-specific antagonists ketanserin and spiperone [27].

Associations of spiperone with other chemical compounds


Gene context of spiperone


Analytical, diagnostic and therapeutic context of spiperone


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  16. Inhibition of cutaneous contact hypersensitivity in the mouse with systemic or topical spiperone: topical application of spiperone produces local immunosuppression without inducing systemic neuroleptic effects. Sharpe, R.J., Chandrasekar, A., Arndt, K.A., Wang, Z.S., Galli, S.J. J. Invest. Dermatol. (1992) [Pubmed]
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  18. Evidence that m-chlorophenylpiperazine-induced hyperthermia in rats is mediated by stimulation of 5-HT2C receptors. Mazzola-Pomietto, P., Aulakh, C.S., Wozniak, K.M., Murphy, D.L. Psychopharmacology (Berl.) (1996) [Pubmed]
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