Disease relevance of BRN 5154193

• In patients of Group II (n = 12), the ability of carocainide to interrupt supraventricular reentrant tachycardia was studied [1].
• Carocainide was effective in the short-term treatment of supraventricular tachycardias [1].
• In 11 of 12 patients (11 patients with regular atrioventricular reentrant tachycardia incorporating an accessory pathway, one patient with AV node reentry), sustained tachycardia was stopped by intravenous injection of carocainide in a dose of 3.5 mg/kg body weight [1].
• Our results suggest that carocainide could be a safe and effective drug for the treatment of ventricular arrhythmias [2].

High impact information on BRN 5154193

• Pharmacokinetics and metabolism of the anti-arrhythmic carocainide in man [3].
• Effect of an antiarrhythmic agent, carocainide, on action potentials of ventricular papillary muscle of the guinea-pig heart in vitro [4].
• Carocainide (5 x 10(-5) M) at 1 Hz caused an appreciable shift (6-7 mV) of the curve at 50% of the maximum upstroke velocity (mid-point), bringing the membrane potential and the maximum upstroke velocity along the voltage axis in the hyperpolarizing direction [4].
• In Purkinje fiber-papillary muscle junction preparations driven at a constant cycle length of 1000 msec, perfusion of carocainide at the concentration of 1.25 10(-5) M and 2.5 10(-5) M, increased conduction time between Purkinje and muscle fibers and decreased the rate of depolarization of Purkinje fibers and papillary muscle [5].
• Effects of MD770207 (carocainide) on experimental ventricular arrhythmias [6].

Biological context of BRN 5154193

• Carocainide, at concentrations above 5 x 10(-6) M, induced a dose-dependent decrease of the maximum upstroke velocity at a stimulation frequency of 0.1 Hz, while the resting membrane potential, the amplitude and duration of action potential were not affected even at 5 x 10(-5) M [4].

Anatomical context of BRN 5154193

• Electrophysiological effects of carocainide (770207) on canine ventricular muscle and Purkinje fibers [7].
• Carocainide also increases the conduction time at the Purkinje papillary muscle junction [7].
• Carocainide reduced epicardial ST-segment elevation produced by short coronary artery occlusion and prevented the occurrence of ventricular fibrillation resulting from reperfusion after acute coronary artery ligation [6].

References