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Chemical Compound Review

CHEMBL331211     1-hydroxy-2,2,6,6- tetramethyl-piperidin-4...

Synonyms: SureCN143973, NSC-239129, AC1Q7DHA, KB-36603, NSC239129, ...
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Disease relevance of Tempamine


High impact information on Tempamine

  • The relative rotational correlation time (tau c) of two spin labels, TEMPONE and TEMPAMINE, respectively, in erythrocyte insides (5.22 +/- 0.42 in diabetics, n = 21 vs 4.79 +/- 0.38, n = 16 in controls, P < 0.005) and in the solutions of in vitro glycated haemoglobin, were increased [2].
  • We present a method for measuring the transmembrane pH difference (deltapH=pHin-pHout) in chloroplasts with a spin label TEMPAMINE (4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl) accumulating inside the thylakoids in response to generation of deltapH [3].
  • By using the basic spin label TEMPAMINE, we showed that the NADH-related redox chain in lysosomes supports proton accumulation in lysosomes [4].
  • The purpose of the present study was to investigate whether the local prevention of luminal superoxide-mediated biological damage in the rat jejunal mucosa could be achieved by liposomal superoxide dismutase (SOD) and the SOD mimic tempamine (TMN) [5].
  • The EPR signal which results when 1 mM TEMPAMINE, 120 mM ferricyanide, and erythrocytes are mixed together arises from TEMPAMINE only in the intracellular aqueous space [6].

Biological context of Tempamine


Anatomical context of Tempamine

  • Experiments with chloroplasts suspended in the media of different osmolarity demonstrated that most of TEMPAMINE (TA) molecules taken up by chloroplasts were localized in the bulk of the thylakoid lumen [3].


  1. Neurophysiological consequences of nitroxide antioxidants. Hahn, S.M., Lepinski, D.L., DeLuca, A.M., Mitchell, J.B., Pellmar, T.C. Can. J. Physiol. Pharmacol. (1995) [Pubmed]
  2. The effects of in vivo and in vitro non-enzymatic glycosylation and glycoxidation on physico-chemical properties of haemoglobin in control and diabetic patients. Watala, C., Golański, J., Witas, H., Gurbiel, R., Gwoździński, K., Trojanowski, Z. Int. J. Biochem. Cell Biol. (1996) [Pubmed]
  3. Determination of a transmembrane pH difference in chloroplasts with a spin label tempamine. Trubitsin, B.V., Tikhonov, A.N. J. Magn. Reson. (2003) [Pubmed]
  4. The existence of a lysosomal redox chain and the role of ubiquinone. Gille, L., Nohl, H. Arch. Biochem. Biophys. (2000) [Pubmed]
  5. Local prevention of oxidative stress in the intestinal epithelium of the rat by adhesive liposomes of superoxide dismutase and tempamine. Jubeh, T.T., Antler, S., Haupt, S., Barenholz, Y., Rubinstein, A. Mol. Pharm. (2005) [Pubmed]
  6. Direct measurement of the internal viscosity of sickle erythrocytes as a function of cell density. Morse, P.D., Warth, J.A. Biochim. Biophys. Acta (1990) [Pubmed]
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