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Chemical Compound Review

SureCN677731     1-(2,4-dihydroxyphenyl)-2- (4...

Synonyms: HMDB04629, SureCN12255054, AR-1K9071, LS-185633, AC1L3HY3, ...
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Disease relevance of O-Desmethylangolensin


High impact information on O-Desmethylangolensin

  • Isoflavone aglycones and their mammalian metabolites equol and O-desmethylangolensin were separated selectively and identified by absorbance patterns, fluorometric and electrochemical detection, gas chromatography-mass spectrometric analysis after trimethylsilylation, and with internal and external authentic standards [3].
  • The prevalence of the equol-producer phenotype was higher (51 vs. 36%; P = 0.015) and the ODMA-producer phenotype was lower (84 vs. 92%, P = 0.03) in KA than in CA women and girls [1].
  • Isoflavonoid concentrations in first-void morning urines, collected after a 3-d soy challenge, were used to establish equol-, and ODMA-producer phenotypes (>44 mug/L) [1].
  • Isoflavones (genistein, daidzein, O-desmethylangolensin, and equol) were measured in two overnight urine collections from 363 women recruited from a health maintenance organization [4].
  • Reductive daidzein-metabolites likely formed by intestinal microflora (equol, O-desmethylangolensin) were excreted with feces in small amounts (< 5% of dose) [5].

Biological context of O-Desmethylangolensin


Analytical, diagnostic and therapeutic context of O-Desmethylangolensin


  1. Prevalence of Daidzein-Metabolizing Phenotypes Differs between Caucasian and Korean American Women and Girls. Song, K.B., Atkinson, C., Frankenfeld, C.L., Jokela, T., Wähälä, K., Thomas, W.K., Lampe, J.W. J. Nutr. (2006) [Pubmed]
  2. Urinary excretion of isoflavonoids and the risk of breast cancer. Zheng, W., Dai, Q., Custer, L.J., Shu, X.O., Wen, W.Q., Jin, F., Franke, A.A. Cancer Epidemiol. Biomarkers Prev. (1999) [Pubmed]
  3. Daidzein and genistein concentrations in human milk after soy consumption. Franke, A.A., Custer, L.J. Clin. Chem. (1996) [Pubmed]
  4. Overnight urinary isoflavone excretion in a population of women living in the United States, and its relationship to isoflavone intake. Atkinson, C., Skor, H.E., Fitzgibbons, E.D., Scholes, D., Chen, C., Wähälä, K., Schwartz, S.M., Lampe, J.W. Cancer Epidemiol. Biomarkers Prev. (2002) [Pubmed]
  5. Disposition and biotransformation of the estrogenic isoflavone daidzein in rats. Bayer, T., Colnot, T., Dekant, W. Toxicol. Sci. (2001) [Pubmed]
  6. Reduced isoflavone metabolites formed by the human gut microflora suppress growth but do not affect DNA integrity of human prostate cancer cells. Raschke, M., Wähälä, K., Pool-Zobel, B.L. Br. J. Nutr. (2006) [Pubmed]
  7. Time-resolved fluoroimmunoassay of plasma and urine O-desmethylangolensin. L'homme, R., Brouwers, E., Al-Maharik, N., Lapcík, O., Hampl, R., Mikola, H., Wähälä, K., Adlercreutz, H. J. Steroid Biochem. Mol. Biol. (2002) [Pubmed]
  8. Urinary phytoestrogen concentrations in the U.S. population (1999-2000). Valentín-Blasini, L., Sadowski, M.A., Walden, D., Caltabiano, L., Needham, L.L., Barr, D.B. Journal of exposure analysis and environmental epidemiology. (2005) [Pubmed]
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