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Chemical Compound Review

h-nip-oh     piperidine-3-carboxylic acid

Synonyms: h-dl-nip-oh, nipecotic acid, PubChem6793, h-dl-pic(3)-oh, SureCN85677, ...
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Disease relevance of nipecotic acid


Psychiatry related information on nipecotic acid


High impact information on nipecotic acid


Biological context of nipecotic acid


Anatomical context of nipecotic acid


Associations of nipecotic acid with other chemical compounds


Gene context of nipecotic acid


Analytical, diagnostic and therapeutic context of nipecotic acid

  • A novel HPLC assay for the determination of nipecotic acid in mouse brain was developed, based on a modification of a reported amino acid analysis procedure [31].
  • The peak outward current induced by nipecotic acid was larger in neurons of the kindled (55.4 +/- 5.7 pA, N=30) than the control group (39.8 +/- 4.5 pA, N=28) (P<0.05) [32].
  • Pretreatments with implantation of a morphine pellet or with phentolamine (10 micrograms IT) or with reserpine (10 mg/kg SC) did not attenuate this analgesia, yet the analgesia was antagonized by GABA mimetics, such as muscimol (0.1 microgram IC), nipecotic acid (100 mg/kg IP) [33].
  • The quantification and identification of PA are accomplished in rat and mouse brain using high performance liquid chromatography with electrochemical detection (LCEC) and nipecotic acid (NPA) as an internal standard [34].


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  22. gamma-Aminobutyric acid-induced modulation of acetylcholine release from the guinea pig lung. Shirakawa, J., Taniyama, K., Tanaka, C. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
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  24. Effects of sodium n-dipropylacetate, muscimol hydrobromide and (R,S) nipecotic acid amide on isolation-induced aggressive behavior in mice. Puglisi-Allegra, S., Mandel, P. Psychopharmacology (Berl.) (1980) [Pubmed]
  25. Use of gamma-aminobutyric acid (GABA)-transaminase inhibitors and a GABA uptake inhibitor to investigate the influence of GABA neurons on dopamine-containing amacrine cells of the rat retina. Proll, M.A., Morgan, W.W. J. Pharmacol. Exp. Ther. (1983) [Pubmed]
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  27. Tiagabine in clinical practice. Genton, P., Guerrini, R., Perucca, E. Epilepsia (2001) [Pubmed]
  28. gamma-Aminobutyric acid (GABA) stimulates somatostatin release following activation of a GABA uptake carrier located on somatostatin nerve endings of rat cerebral cortex. Raiteri, M., Bonanno, G., Fedele, E., Fontana, G., Gemignani, A. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  29. A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor. Suzdak, P.D., Jansen, J.A. Epilepsia (1995) [Pubmed]
  30. Postsynaptic action of endogenous GABA released by nipecotic acid in the hippocampus. Solís, J.M., Nicoll, R.A. Neurosci. Lett. (1992) [Pubmed]
  31. Determination of m-nitrophenol and nipecotic acid in mouse tissues by high-performance liquid chromatography after administration of the anticonvulsant m-nitrophenyl-3-piperidinecarboxylate hydrochloride. Nassereddine-Sebaei, M., Crider, A.M., Carroll, R.T., Hinko, C.N. Journal of pharmaceutical sciences. (1993) [Pubmed]
  32. Partial hippocampal kindling increases GABAB receptor-mediated postsynaptic currents in CA1 pyramidal cells. Liu, X., Leung, L.S. Epilepsy Res. (2003) [Pubmed]
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  34. Quantitative determination and regional distribution of pipecolic acid in rodent brain. Kim, J.S., Giacobini, E. Neurochem. Res. (1984) [Pubmed]
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