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Chemical Compound Review:

Phoslex A 2 ethanol; phosphoric acid

Synonyms: AC1L3PPJ, AC1Q6RTN, AR-1I7611, JP 502, D 24340, ...

Bicker, W. et al., Masugi, F. et al., TSinger, B. et al., Ray, W.J. et al.

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Disease relevance of Ethyl orthophosphate

The blood pressure of rats with established hypertension produced by clipping one renal artery and contralateral nephrectomy normally decreases rapidly after unclipping the renal artery, but the initial rapid decrease was significantly inhibited by an intravenous infusion of 3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl-2-thiazolio ethyl phosphate [1].

High impact information on Ethyl orthophosphate

Validated method for the determination of the ethanol consumption markers ethyl glucuronide, ethyl phosphate, and ethyl sulfate in human urine by reversed-phase/weak anion exchange liquid chromatography-tandem mass spectrometry [2].
The rate of PO3 transfer to water is increased by up to 1000-fold by binding entities that provide the active site with a second PO3 group, e.g., ethyl phosphate or inorganic phosphite [3].
Upon either U4A RNase or acid hydrolysis up to 60% of the radioactivity is found as volatile ethyl groupw in the form of [14C]ethanol, and a further 15% appears to be primarily ethyl phosphate and nucleosides with ethylated phosphate [4].

Associations of Ethyl orthophosphate with other chemical compounds

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of the ethanol consumption markers ethyl glucuronide (EtG), ethyl phosphate (EtP), and ethyl sulfate (EtS) in human urine was developed [2].

References

The role of antihypertensive polar renomedullary lipid in the pathogenesis of hypertension. Masugi, F., Ogihara, T., Otsuka, A., Saeki, S., Kumahara, Y. Jpn. Circ. J. (1984) [Pubmed]
Validated method for the determination of the ethanol consumption markers ethyl glucuronide, ethyl phosphate, and ethyl sulfate in human urine by reversed-phase/weak anion exchange liquid chromatography-tandem mass spectrometry. Bicker, W., Lämmerhofer, M., Keller, T., Schuhmacher, R., Krska, R., Lindner, W. Anal. Chem. (2006) [Pubmed]
An analysis of the substrate-induced rate effect in the phosphoglucomutase system. Ray, W.J., Long, J.W., Owens, J.D. Biochemistry (1976) [Pubmed]
The specificity of different classes of ethylating agents toward various sites in RNA. TSinger, B., Fraenkel-Conrat, H. Biochemistry (1975) [Pubmed]

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