Psychiatry related information on Ethyl glucuronide

• The analysis of ethyl glucuronide (EtG), a marker of recent alcohol consumption, in serum with an optimized CZE assay is reported [1].
• Fatty acid ethyl esters and ethyl glucuronide in hair have proven to be suitable markers for alcohol abuse [2].
• Ethyl glucuronide: a biomarker to identify alcohol use by health professionals recovering from substance use disorders [3].

High impact information on Ethyl glucuronide

• A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of the ethanol consumption markers ethyl glucuronide (EtG), ethyl phosphate (EtP), and ethyl sulfate (EtS) in human urine was developed [4].
• We therefore investigated three new markers and compared their kinetics and sensitivities: (1) fatty acid ethyl esters (FAEEs) in serum, (2) ethyl glucuronide (EtG) in urine, and (3) the ratio of 5-hydroxytryptophol to 5-hydroxyindole acetic acid (5-HTOL/5-HIAA) in urine [5].
• Wurst; (3) Sialic Acid Index of Plasma Apolipoprotein J (SIJ) as a Viable Marker for Chronic Alcohol Consumption, by Philippe Marmillot; (4) The Emergence of Ethyl Glucuronide (EtG) Testing as a Tool in Monitoring Healthcare Professionals, by Gregory E [6].
• RESULTS:: 5-Hydroxytryptophol glucuronide was measured by ELISA with good analytical precision, its diagnostic specificity and sensitivity was better than that of 5-hydroxytryptophol and its correlation was closer to ethyl glucuronide than to 5-hydroxytryptophol [7].
• Distribution of ethyl glucuronide in rib bone marrow, other tissues and body liquids as proof of alcohol consumption before death [8].

Chemical compound and disease context of Ethyl glucuronide

• Urinary tract infection: a risk factor for false-negative urinary ethyl glucuronide but not ethyl sulfate in the detection of recent alcohol consumption [9].

Biological context of Ethyl glucuronide

• A kinetic model describing the pharmacokinetics of ethyl glucuronide in humans [10].
• This study compared the urinary excretion characteristics of ethyl glucuronide (EtG) with that of ethanol, with focus on the effect of water-induced diuresis [11].

Anatomical context of Ethyl glucuronide

• Assessment of UDP-glucuronosyltransferase catalyzed formation of ethyl glucuronide in human liver microsomes and recombinant UGTs [12].
• Postmortem ethyl glucuronide (EtG) concentrations in rib bone marrow, liver, muscle, fat tissue, urine, blood and bile have been determined by LC-MS/MS [8].
• Can ethyl glucuronide be determined in post-mortem body fluids and tissues [13]?
• The stability of ethyl glucuronide (EtG) under conditions of degradation was examined in urine samples of nine volunteers and in post-mortem tissue (liver, skeletal muscle) and blood taken from seven corpses at autopsies [14].

Associations of Ethyl glucuronide with other chemical compounds

• While ethanol is primarily metabolized to acetaldehyde and acetic acid via alcohol dehydrogenase, a minor but increasingly important pathway in the field of forensic science involves the conjugation of glucuronic acid to form an ethyl glucuronide (EtG) metabolite [12].

Analytical, diagnostic and therapeutic context of Ethyl glucuronide

• Determination of ethyl glucuronide in hair samples by liquid chromatography/electrospray tandem mass spectrometry [15].
• Analysis of ethyl glucuronide in human serum by capillary electrophoresis with sample self-stacking and indirect detection [16].
• Ethyl glucuronide concentration in serum of human volunteers, teetotalers, and suspected drinking drivers [17].
• An improved method for the determination of ethyl glucuronide (EtG) in human serum and urine was developed using solid-phase extraction (SPE) and gas chromatography (GC) with mass spectrometric detection (MS) [18].

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