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Chemical Compound Review:

Bucarban 3-(4-aminophenyl)sulfonyl-1- butyl-urea

Synonyms: Bukarban, Diabetal, Glucidoral, Oranil, Oranyl, ...

Kees, F. et al., Pogátsa, G. et al., Debeer, L.J. et al., Pogátsa, G. et al., Debeer, L.J. et al., et al.

Durlik, Rauch, Thyroff-Friesinger, Streu, Paczek,

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Disease relevance of Oranyl

Carbutamide was totally effective in the prevention and treatment of P. carinii pneumonitis in dosages of 100 and 200 mg/kg per day [1].
In rabbits and rats glibenclamide (0.0032-100 mumol. kg-1) decreased, while tolbutamide and carbutamide (0.008-1000 mumol. kg-1) increased strophantidin toxicity and myocardial ischaemia induced transitory ventricular fibrillation dose-dependently [2].

High impact information on Oranyl

Chlorpropamide, tolbutamide, and carbutamide, all of which inhibited endogenous ketogenesis in isolated liver cells, also inhibited lysosomal triglyceride lipase activity in rat liver homogenates [3].
Agglutination of the patient's serum also occurred with erythrocytes treated with other sulfonylureas (chlorpropamide, glibenclamide, carbutamide) but not with phenacetin [4].
Metabolic effects of hypoglycemic sulfonylureas-VI. Effects of chlorpropamide and carbutamide on ketogenesis and on mitochondrial redox state in the isolated perfused rat liver [5].
The aim of this study was to compare the bioavailability of cyclosporine (CyA) from the generic dispersion formulation Cicloral (CIC) with the microemulsion formulation Neoral (NEO) and the original Sandimmune (SIM) capsules after single doses of 100, 300, or 600 mg of drug, respectively [6].
Effect of simultaneous administration of drugs on absorption and excretion. X. Plasma protein binding of carbutamide in rabbits [7].

Biological context of Oranyl

Comparative bioavailability of the microemulsion formulation of cyclosporine (neoral) with a generic dispersion formulation (cicloral) in young healthy male volunteers [6].
Bioequivalence could not be proven either between Cicloral and Neoral, or between Cicloral fasting versus after a fat-rich meal [8].
Apart from a considerable rise of arterial blood pressure during carbutamide treatment, no other difference was found in the cardiac actions of the three hypoglycemic agents tested [9].

Analytical, diagnostic and therapeutic context of Oranyl

In kidney transplant recipients we investigated whether this conclusion applies also to a new dispersion formulation of cyclosporine (Cicloral) [10].

References

Effects of sulfonylurea compounds on Pneumocystis carinii. Hughes, W.T., Smith-McCain, B.L. J. Infect. Dis. (1986) [Pubmed]
The effect of various hypoglycaemic sulphonylureas on the cardiotoxicity of glycosides and arrhythmogenic activity due to myocardial ischaemia. Pogátsa, G., Koltai, M.Z., Balkányi, I., Dévai, I., Kiss, V., Köszeghy, A. Acta physiologica Hungarica. (1988) [Pubmed]
Effect of sulfonylureas on triglyceride metabolism in the rat liver: possible role of the lysosomes in hepatic lipolysis. Debeer, L.J., Thomas, J., Mannaerts, G., DeSchepper, P.J. J. Clin. Invest. (1977) [Pubmed]
Tolbutamide-induced hemolytic anemia. Malacarne, P., Castaldi, G., Bertusi, M., Zavagli, G. Diabetes (1977) [Pubmed]
Metabolic effects of hypoglycemic sulfonylureas-VI. Effects of chlorpropamide and carbutamide on ketogenesis and on mitochondrial redox state in the isolated perfused rat liver. Debeer, L.J., Mannaerts, G., De Schepper, P.J. Biochem. Pharmacol. (1975) [Pubmed]
Comparative bioavailability of the microemulsion formulation of cyclosporine (neoral) with a generic dispersion formulation (cicloral) in young healthy male volunteers. Kees, F., Bucher, M., Schweda, F., Gschaidmeier, H., Burhenne, J., Mikus, G., Faerber, L. Therapeutic drug monitoring. (2006) [Pubmed]
Effect of simultaneous administration of drugs on absorption and excretion. X. Plasma protein binding of carbutamide in rabbits. Imamura, Y., Sonoda, M., Arimori, K., Ichibagase, H. Chem. Pharm. Bull. (1979) [Pubmed]
Cicloral versus neoral: a bioequivalence study in healthy volunteers on the influence of a fat-rich meal on the bioavailability of cicloral. Kees, F., Mair, G., Dittmar, M., Bucher, M. Transplant. Proc. (2004) [Pubmed]
Effect of diabetes therapy on the myocardium in experimental diabetes. Pogátsa, G., Bihari-Varga, M., Szinay, G. Acta diabetologica latina. (1979) [Pubmed]
Comparison of peak and trough level monitoring of cyclosporine treatment using two modern cyclosporine preparations. Durlik, M., Rauch, C., Thyroff-Friesinger, U., Streu, H., Paczek, L. Transplant. Proc. (2003) [Pubmed]

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