Disease relevance of Phenyl pyruvic acid

• Untreated phenylketonuria (PKU) is characterized by excretion of phenylpyruvic acid in the urine and mental retardation [1].
• Phenylalanine utilization for protein synthesis in beta-phenylpyruvic acid treated Escherichia coli cells [2].

High impact information on Phenyl pyruvic acid

• Cobalt(II)-catalyzed chemiluminescence in a dioctadecyldimethylammonium chloride bilayer membranous medium for the flow injection determination of phenylpyruvic acid [3].
• Identification and quantification of 3-methoxy-4-hydroxyphenyllactic acid (VLA) in cerebrospinal fluid and 3-methoxy-4-hydroxy phenylpyruvic acid (VPA) in the urine of Parkinsonian patients treated with L-DOPA [4].
• In studies in vitro it was observed that the incorporation of the radioactivity from [14C]acetoacetate and 3-hydroxy[14C]butyrate into cerebral lipids was inhibited by phenyl-pyruvate, but not by phenylalanine [5].
• The comparative formation of phenylalanine and phenylpyruvic acid in the reaction of 4,5-epoxy-2-decenal with phenylalanine was studied to determine whether epoyalkenals may also degrade amino acids without producing their decarboxylation [6].
• Ferrichrome, rhodotorulic acid, desferoxamine mesylate and 2,3-dihydroxybenzoic acid were found to inhibit the MMP-2 activity whereas beta-phenylpyruvic acid had no effect [7].

Chemical compound and disease context of Phenyl pyruvic acid

• There is a steady and nonlinear relationship between the levels of both phenylpyruvic acid (PPA) and o-hydroxyphenylacetic acid (oOPAA) in urine and the plasma levels of phenylalanine (phe) in children more than two years of age with phenylketonuria (PKU) [8].

Biological context of Phenyl pyruvic acid

• As a possibility the defective decarboxylation of phenylpyruvic acid is proposed [9].
• The use of engineered phenylalanine dehydrogenase N145A supported on Celite for the reductive amination of phenylpyruvic acid in homogeneous and biphasic aqueous-organic solvents is reported [10].

Associations of Phenyl pyruvic acid with other chemical compounds

• The major catabolites detected by gas chromatography in the urines of infected animals were phenylpyruvic acid, 4-hydroxyphenylpyruvic acid, and indole-3-pyruvic acid [11].

Gene context of Phenyl pyruvic acid

• [14C]-Benzylmalic acid was synthesized from beta-phenylpyruvic acid with [14C]-acetyl-CoA in the S10 fraction [12].

Analytical, diagnostic and therapeutic context of Phenyl pyruvic acid

• Determination of alpha-keto acids including phenylpyruvic acid in human plasma by high-performance liquid chromatography with chemiluminescence detection [13].
• This sensitivity permits precise determination of several alpha-keto acids including phenylpyruvic acid, which cannot be determined by other HPLC methods, in 10 microliters of normal human plasma [13].

References