Disease relevance of Acetohydroxamic acid, N,N'-((3,6-dioxo-2,5-piperazinediyl)bis(trimethylene)di-, L-

• The fhuE gene of Escherichia coli codes for an outer-membrane receptor protein required for the uptake of iron(III) via coprogen, ferrioxamine B and rhodotorulic acid [1].

High impact information on Acetohydroxamic acid, N,N'-((3,6-dioxo-2,5-piperazinediyl)bis(trimethylene)di-, L-

• Fre4p could facilitate utilization of rhodotorulic acid-iron when the siderophore was present in higher concentrations [2].
• The H. capsulatum siderophore dimerum acid and the structurally similar basidiomycete siderophore rhodotorulic acid acted as substrates for the ferric reductase, and rhodotorulic acid removed Fe(III) bound by transferrin [3].
• The results show that the relative rates of reaction of these hydroxamate derivatives with ferryl myoglobin are N-methyl-N-hexanoyl hydroxylamine > N-methyl-N-benzoyl hydroxylamine > N-methyl-N-acetyl hydroxylamine > desferrioxamine > rhodotorulic acid > N-methyl-N-butyryl hydroxylamine [4].
• Deferrioxamine B and rhodotorulic acid, iron-chelating agents of microbial origin, exerted a pronounced inhibitory effect on pathogenic Naegleria fowleri at microgram levels [5].
• Cajanus cajan rhizobial isolates were found to be unable to utilize iron bound to ferrichrome, desferrioxamine B or rhodotorulic acid, all being hydroxamate type siderophores [6].

Biological context of Acetohydroxamic acid, N,N'-((3,6-dioxo-2,5-piperazinediyl)bis(trimethylene)di-, L-

• Kinetics and mechanism of iron(III) dissociation from the dihydroxamate siderophores alcaligin and rhodotorulic acid [7].
• The production of rhodotorulic acid, a siderophore synthesized by Rhodotorula strains, was improved with the objective of achieving the biocontrol of phytopathogenic moulds [8].

Associations of Acetohydroxamic acid, N,N'-((3,6-dioxo-2,5-piperazinediyl)bis(trimethylene)di-, L- with other chemical compounds

• The kinetics and mechanism of siderophore ligand dissociation from their fully chelated Fe(III) complexes is described for the highly preorganized cyclic tetradentate alcaligin and random linear tetradentate rhodotorulic acid in aqueous solution at 25 degrees C (Fe2L3 + 6H+ reversible 2 Fe3+ aq + 3 H2L) [7].
• The release of iron from horse spleen ferritin by the chelating agents desferrioxamine B, rhodotorulic acid, 2,3-dihydroxybenzoate, 2,2'-bipyridyl and pyridine-2-aldehyde-2-pyridyl hydrazone (Paphy) has been studied in vitro [9].

Analytical, diagnostic and therapeutic context of Acetohydroxamic acid, N,N'-((3,6-dioxo-2,5-piperazinediyl)bis(trimethylene)di-, L-

• Aqueous solutions of Fe3+ complexes of cyclic (alcaligin) and linear (rhodotorulic acid) dihydroxamate siderophores and synthetic linear eight-carbon-chain and two-carbon-chain dihydroxamic acids ([CH3N(OH)C=O)]2(CH2)n; H2Ln; n = 2 and 8) were investigated by electrospray ionization mass spectrometry (ESI-MS) [10].

References