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Chemical Compound Review

indolepyruvate     3-(1H-indol-3-yl)-2-oxo- propanoic acid

Synonyms: PubChem7282, ARONIS24313, I5567_ALDRICH, I7017_ALDRICH, CHEMBL485012, ...
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Disease relevance of beta-Indolylpyruvic acid


High impact information on beta-Indolylpyruvic acid


Gene context of beta-Indolylpyruvic acid


Analytical, diagnostic and therapeutic context of beta-Indolylpyruvic acid

  • In a single-blind study six male patients (mean age 39.5 years) with moderate insomnia were treated with placebo for three nights, 100 mg indole-3-pyruvic acid (IPA) for three nights, 200 mg IPA for three nights, 100 mg IPA for two nights and placebo for two nights [9].


  1. Cloning and characterization of a locus encoding an indolepyruvate decarboxylase involved in indole-3-acetic acid synthesis in Erwinia herbicola. Brandl, M.T., Lindow, S.E. Appl. Environ. Microbiol. (1996) [Pubmed]
  2. Evidence for production of the phytohormone indole-3-acetic acid by cyanobacteria. Sergeeva, E., Liaimer, A., Bergman, B. Planta (2002) [Pubmed]
  3. Synthesis of phytohormones by plant-associated bacteria. Costacurta, A., Vanderleyden, J. Crit. Rev. Microbiol. (1995) [Pubmed]
  4. Effect of tryptophan and its metabolites on gastric emptying of liquid meals in dogs. Cooke, A.R., Ward, W.O. Proc. Soc. Exp. Biol. Med. (1976) [Pubmed]
  5. Studies on structure-function relationships of indolepyruvate decarboxylase from Enterobacter cloacae, a key enzyme of the indole acetic acid pathway. Schütz, A., Golbik, R., Tittmann, K., Svergun, D.I., Koch, M.H., Hübner, G., König, S. Eur. J. Biochem. (2003) [Pubmed]
  6. Evidence for the presence of DNA-binding proteins involved in regulation of the gene expression of indole-3-pyruvic acid decarboxylase, a key enzyme in indole-3-acetic acid biosynthesis in Azospirillum lipoferum FS. Yagi, K., Chujo, T., Nojiri, H., Omori, T., Nishiyama, M., Yamane, H. Biosci. Biotechnol. Biochem. (2001) [Pubmed]
  7. A novel enzyme, L-tryptophan oxidase, from a basidiomycete, Coprinus sp. SF-1: purification and characterization. Furuya, Y., Sawada, H., Hirahara, T., Ito, K., Ohshiro, T., Izumi, Y. Biosci. Biotechnol. Biochem. (2000) [Pubmed]
  8. Antioxidant properties of indole-3-pyruvic acid. Politi, V., D'Alessio, S., Di Stazio, G., De Luca, G. Adv. Exp. Med. Biol. (1996) [Pubmed]
  9. Indole-3-pyruvic acid as a possible hypnotic agent in insomniac subjects. Silvestri, R., Mento, G., Raffaele, M., De Luca, G., Buttini, G., Casella, C., Tisano, A., De Domenico, P., Di Rosa, A.E., Di Perri, R. J. Int. Med. Res. (1991) [Pubmed]
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