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Gene Review

YAF2  -  YY1 associated factor 2

Homo sapiens

Synonyms: YY1-associated factor 2
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Disease relevance of YAF2


High impact information on YAF2

  • These phenotypes can be rescued by co-injection of human YAF2 mRNA with the morpholinos or by treatment with a pan-caspase inhibitor or a caspase 8-specific inhibitor [2].
  • Yaf2 Inhibits Caspase 8-mediated Apoptosis and Regulates Cell Survival during Zebrafish Embryogenesis [2].
  • Our findings implicate Yaf2 as a survival factor during early zebrafish development and organogenesis [2].
  • We identified a human cDNA encoding a protein related to YAF-2 (YY1-associated factor 2), which was previously isolated as an interacting partner of the Ying-Yang-1 (YY1) transcription factor [3].
  • These cofactors are functionally different in that YAF-2 positively regulates the transcriptional activity of hGABP but YEAF1 negatively regulates this activity [3].

Biological context of YAF2

  • The YAF2 cDNA encodes a 180 amino acid basic protein (pI 10.5) containing a single N-terminal C2-X10-C2 zinc finger [4].
  • The isolation of YAF2 may help in understanding the mechanisms through which inhibitors of myogenic transcription may be antagonized or eliminated by proteolysis during muscle development [4].
  • In contrast to the down-regulation of YY1, YAF2 message levels increase during in vitro differentiation of both rat skeletal and cardiac muscle cells [4].
  • We show that the murine YAF2 locus generates two different transcripts, mYAF2-a and mYAF2-b by alternative splicing of the third exons which encode two YAF2 isoforms of 179 and conceptual 60 amino acids, respectively [5].
  • Partial depletion of Yaf2, achieved by injecting lower dosages of morpholino, circumvents the early arrest but leads to CNS degeneration associated with excessive apoptosis [2].

Anatomical context of YAF2

  • YAF2 appears to have a promyogenic regulatory role, since overexpression of YAF2 in C2 myoblasts stimulates myogenic promoter activity normally restricted by YY1 [4].
  • Also, YAF-2 mRNA is highly expressed in skeletal muscle, whereas YEAF1 mRNA is highly expressed in placenta [3].
  • Finally, the observed activation of caspase 8 in the morphants is in accord with the ability of Yaf2 to inhibit caspase 8-mediated apoptosis in cultured cells [2].
  • Endogenous Yaf2 is expressed in all three tested neuroblastoma cell lines, all of which also express MycN [1].

Other interactions of YAF2

  • Among them, YAF2 and AMIGO2 were the most plausible candidates to affect growth and psychomotor retardation, respectively, in both cases [6].


  1. Functional interaction of Yaf2 with the central region of MycN. Bannasch, D., Mädge, B., Schwab, M. Oncogene (2001) [Pubmed]
  2. Yaf2 Inhibits Caspase 8-mediated Apoptosis and Regulates Cell Survival during Zebrafish Embryogenesis. Stanton, S.E., McReynolds, L.J., Evans, T., Schreiber-Agus, N. J. Biol. Chem. (2006) [Pubmed]
  3. YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors. Sawa, C., Yoshikawa, T., Matsuda-Suzuki, F., Deléhouzée, S., Goto, M., Watanabe, H., Sawada, J., Kataoka, K., Handa, H. J. Biol. Chem. (2002) [Pubmed]
  4. Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. Kalenik, J.L., Chen, D., Bradley, M.E., Chen, S.J., Lee, T.C. Nucleic Acids Res. (1997) [Pubmed]
  5. The mouse YAF2 gene generates two distinct transcripts and is expressed in pre-and postimplantation embryos. Kaneko, T., Miyagishima, H., Hasegawa, T., Mizutani-Koseki, Y., Isono, K., Koseki, H. Gene (2003) [Pubmed]
  6. Phenotype-genotype correlation in two patients with 12q proximal deletion. Miyake, N., Tonoki, H., Gallego, M., Harada, N., Shimokawa, O., Yoshiura, K., Ohta, T., Kishino, T., Niikawa, N., Matsumoto, N. J. Hum. Genet. (2004) [Pubmed]
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