Disease relevance of xylB

• Structural and Kinetic Studies of Induced Fit in Xylulose Kinase from Escherichia coli [1].
• The deduced proteins of the last two genes on the fragment showed a high similarity to a fructokinase from Vibrio alginolyticus (MtlZ) and a xylulose kinase from Streptomyces rubiginosus (MtlY), respectively [2].

High impact information on xylB

• Xylulose kinase (XK; EC 2.7.1.17) phosphorylates d-xylulose, the last step in this conversion [1].
• A cytosolic Arabidopsis d-xylulose kinase catalyzes the phosphorylation of 1-deoxy-d-xylulose into a precursor of the plastidial isoprenoid pathway [3].
• It was identified by mass spectrometry as a cytosolic protein bearing d-xylulose kinase (XK) signatures, already suggesting that DX is phosphorylated within the cytosol prior to translocation into the plastids [3].
• A 4.2-kilobase-pair fragment of the Escherichia coli chromosome which contains the genes for xylose isomerase and xylulose kinase was cloned into plasmid pBR322 [4].

Biological context of xylB

• The gene encoding the plastidic protein annotated as "xylulose kinase" might in fact yield an enzyme having different phosphorylation specificities [3].

References