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Gene Review

H52  -  histocompatibility 52

Mus musculus

Synonyms: H(go), H(pi), H56
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Disease relevance of H52


High impact information on H52

  • Since the transcripts were not found in normal C57BL/6 tissues of fetus, newborn, and adult origin, the H52 expression is associated with transforming phenotypes [1].
  • In this study we describe the epitope of the mAb H52 which has been mapped to a predicted disulfide-bonded loop (C386 and C400) in the beta2 integrin subunit [4].
  • We have describe the production of monoclonal anti-idiotype antibodies against one of the anti-CD18 antibodies (H52) which has been shown to inhibit potently the function of leukocyte adhesion receptors [5].
  • Whereas the cross-reactive anti-human beta-subunit antibody H52 profoundly inhibited mitogenic and allogenic stimulation of porcine T lymphocytes as well as cytotoxic T cell and natural killer (NK) cell function, the anti-porcine LFA-1 monoclonal antibodies had very limited effect on porcine lymphocyte function [6].
  • Components H51 and H53 had a higher and a lower molecular weight, respectively, than H52 [7].

Associations of H52 with chemical compounds


  1. Molecular cloning and characterization of the gene encoding mouse melanoma antigen by cDNA library transfection. Hayashi, H., Matsubara, H., Yokota, T., Kuwabara, I., Kanno, M., Koseki, H., Isono, K., Asano, T., Taniguchi, M. J. Immunol. (1992) [Pubmed]
  2. Edema disease in a California sea lion. Diamond, S.S., Raflo, C.P., Beleau, M.H., Cadwell, G.A. J. Am. Vet. Med. Assoc. (1980) [Pubmed]
  3. Retrovirus-mediated gene transfer of transthyretin and transthyretin-methionine 30: a potential tool for the study of amyloidogenesis. Bonifácio, M.J., Ezzeddine, D., Sakaki, Y., Breakfield, X.O., Saraiva, M.J. Neuromuscul. Disord. (1993) [Pubmed]
  4. Expression of the H52 epitope on the beta2 subunit is dependent on its interaction with the alpha subunits of the leukocyte integrins LFA-1, Mac-1 and p150,95 and the presence of Ca2+. Al-Shamkhani, A., Law, S.K. Eur. J. Immunol. (1998) [Pubmed]
  5. Production and characterization of monoclonal anti-CD18 anti-idiotype antibodies. Hildreth, J.E., Hyman, J.A. Mol. Immunol. (1989) [Pubmed]
  6. Monoclonal antibodies against porcine LFA-1: species cross-reactivity and functional effects of beta-subunit-specific antibodies. Hildreth, J.E., Holt, V., August, J.T., Pescovitz, M.D. Mol. Immunol. (1989) [Pubmed]
  7. Isolation, purification, and structure of components from acidic polysaccharides of Pleurotus ostreatus (Fr.) Quél. Yoshioka, Y., Emori, M., Ikekawa, T., Fukuoka, F. Carbohydr. Res. (1975) [Pubmed]
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