Disease relevance of H52

• We also demonstrate that CTL against H52 transfectant kills B16 melanoma [1].
• We have isolated a cDNA (H52) of 2.8-kb-long encoding an 80-kDa mouse melanoma Ag that is defined by a syngeneic anti-B16 melanoma mAb with an ability to block anti-melanoma cytotoxic T cell responses [1].
• Nucleotide sequence analysis has clearly demonstrated that H52 cDNA encodes the full length of the env gene and long terminal repeat region of endogenous ecotropic murine leukemia provirus of AKV-type, which is defective in C57BL/6 [1].
• A beta-hemolytic Escherichia coli, serotype 0147:K . :H52, was the predominant organism isolated from the gastrointestinal tract [2].
• After transfection of the packaging cell line, psi 2, viral stocks were used to infect a rat hepatoma cell line, H56, mouse fibroblast cell line, NIH3T3, and mouse primary fibroblasts [3].

High impact information on H52

• Since the transcripts were not found in normal C57BL/6 tissues of fetus, newborn, and adult origin, the H52 expression is associated with transforming phenotypes [1].
• In this study we describe the epitope of the mAb H52 which has been mapped to a predicted disulfide-bonded loop (C386 and C400) in the beta2 integrin subunit [4].
• We have describe the production of monoclonal anti-idiotype antibodies against one of the anti-CD18 antibodies (H52) which has been shown to inhibit potently the function of leukocyte adhesion receptors [5].
• Whereas the cross-reactive anti-human beta-subunit antibody H52 profoundly inhibited mitogenic and allogenic stimulation of porcine T lymphocytes as well as cytotoxic T cell and natural killer (NK) cell function, the anti-porcine LFA-1 monoclonal antibodies had very limited effect on porcine lymphocyte function [6].
• Components H51 and H53 had a higher and a lower molecular weight, respectively, than H52 [7].

Associations of H52 with chemical compounds

• Component H52 was a heteropolysaccharide made up of alpha-linked galactose and mannose residues [7].

References