Gene Review:
Itgal - integrin alpha L
Mus musculus
Synonyms:
(p180), CD11 antigen-like family member A, Cd11a, Integrin alpha-L, LFA-1, ...
- LFA-1 is required for retention of effector CD8 T cells in mouse lungs. Thatte, J., Dabak, V., Williams, M.B., Braciale, T.J., Ley, K. Blood (2003)
- Purification and structural characterization of LFA-1, a lymphocyte function-associated antigen, and Mac-1, a related macrophage differentiation antigen associated with the type three complement receptor. Kürzinger, K., Springer, T.A. J. Biol. Chem. (1982)
- Rapid development of murine AIDS is dependent of signals provided by CD54 and CD11a. Makino, M., Yoshimatsu, K., Azuma, M., Okada, Y., Hitoshi, Y., Yagita, H., Takatsu, K., Komuro, K. J. Immunol. (1995)
- Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. Ding, Z.M., Babensee, J.E., Simon, S.I., Lu, H., Perrard, J.L., Bullard, D.C., Dai, X.Y., Bromley, S.K., Dustin, M.L., Entman, M.L., Smith, C.W., Ballantyne, C.M. J. Immunol. (1999)
- Aggravated Lyme carditis in CD11a-/- and CD11c-/- mice. Guerau-de-Arellano, M., Alroy, J., Bullard, D., Huber, B.T. Infect. Immun. (2005)
- Induction of tolerance in murine autoimmune diabetes by transient blockade of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 pathway. Moriyama, H., Yokono, K., Amano, K., Nagata, M., Hasegawa, Y., Okamoto, N., Tsukamoto, K., Miki, M., Yoneda, R., Yagi, N., Tominaga, Y., Kikutani, H., Hioki, K., Okumura, K., Yagita, H., Kasuga, M. J. Immunol. (1996)
- A subset of T cell receptors associated with L3T4 molecules mediates C6VL leukemia cell binding of its cognate retrovirus. O'Neill, H.C., McGrath, M.S., Allison, J.P., Weissman, I.L. Cell (1987)
- NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Beilke, J.N., Kuhl, N.R., Van Kaer, L., Gill, R.G. Nat. Med. (2005)
- Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion glycoproteins and unexpected relation to leukocyte interferon. Springer, T.A., Teplow, D.B., Dreyer, W.J. Nature (1985)
- LFA-1 but not Lyt-2 is associated with killing activity of cytotoxic T lymphocyte hybridomas. Kaufmann, Y., Golstein, P., Pierres, M., Springer, T.A., Eshhar, Z. Nature (1982)
- The genetic deficiency of leukocyte surface glycoprotein Mac-1, LFA-1, p150,95 in humans is associated with defective antibody-dependent cellular cytotoxicity in vitro and defective protection against herpes simplex virus infection in vivo. Kohl, S., Loo, L.S., Schmalstieg, F.S., Anderson, D.C. J. Immunol. (1986)
- Lymphocyte function-associated antigen 1 (LFA-1) contains sulfated N-linked oligosaccharides. Dahms, N.M., Hart, G.W. J. Immunol. (1985)
- Pertussis toxin inhibition of T-cell hybridoma invasion is reversed by manganese-induced activation of LFA-1. La Rivière, G., Klein Gebbinck, J.W., Driessens, M.H., Roos, E. J. Cell. Sci. (1994)
- Suppression of atopic-like dermatitis by treatment with antibody to lymphocyte function-associated antigen-1 in NC/Nga mouse. Ohmura, T., Konomi, A., Satoh, Y., Hayashi, T., Tsunenari, I., Kadota, T., Panzenbeck, M.J., Satoh, H. Eur. J. Pharmacol. (2004)
- Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. Sanchez-Madrid, F., Simon, P., Thompson, S., Springer, T.A. J. Exp. Med. (1983)
- The Ly-15 alloantigenic system: a genetically determined polymorphism of the murine lymphocyte function-associated antigen-1 molecule. Hogarth, P.M., Walker, I.D., McKenzie, I.F., Springer, T.A. Proc. Natl. Acad. Sci. U.S.A. (1985)
- The role of LFA-1/ICAM-1 interactions during murine T lymphocyte development. Fine, J.S., Kruisbeek, A.M. J. Immunol. (1991)
- Differential expression of lymphocyte function-associated antigen 1 (LFA-1) on epidermotropic and non-epidermotropic T-cell clones. Shiohara, T., Moriya, N., Gotoh, C., Hayakawa, J., Saizawa, K., Yagita, H., Nagashima, M. J. Invest. Dermatol. (1989)
- Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. Nakajima, H., Sano, H., Nishimura, T., Yoshida, S., Iwamoto, I. J. Exp. Med. (1994)
- The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha4 integrin in the inflammatory response of neutrophils. Henderson, R.B., Lim, L.H., Tessier, P.A., Gavins, F.N., Mathies, M., Perretti, M., Hogg, N. J. Exp. Med. (2001)
- The role of LFA-1 (CD11a/CD18) cytoplasmic domains in binding to intercellular adhesion molecule-1 (CD54) and in postreceptor cell spreading. Pyszniak, A.M., Carpenito, C., Takei, F. Exp. Cell Res. (1997)
- A statin-based inhibitor of lymphocyte function antigen-1 protects against ischemia/reperfusion-induced leukocyte adhesion in the colon. Wan, M.X., Schramm, R., Klintman, D., Welzenbach, K., Weitz-Schmidt, G., Thorlacius, H. Br. J. Pharmacol. (2003)
- Prostaglandin E1 inhibits TNF alpha-induced T-cell adhesion to endothelial cells by selective down-modulation of ICAM-1 expression on endothelial cells. Weiss, J.M., Pilarski, K.A., Weyl, A., Peschen, M., Schöpf, E., Vestweber, D., Vanscheidt, W., Simon, J.C. Exp. Dermatol. (1995)
- LFA-1 binding site in ICAM-3 contains a conserved motif and non-contiguous amino acids. Sadhu, C., Lipsky, B., Erickson, H.P., Hayflick, J., Dick, K.O., Gallatin, W.M., Staunton, D.E. Cell Adhes. Commun. (1994)
- LFA-1-mediated costimulation of CD8+ T cell proliferation requires phosphatidylinositol 3-kinase activity. Ni, H.T., Deeths, M.J., Mescher, M.F. J. Immunol. (2001)
- Ligation of CD3 triggers transmembrane proximity between LFA-1 and cortical microfilaments in a cytotoxic T cell clone derived from tumor infiltrating lymphocytes: a quantitative resonance energy transfer microscopy study. Poo, H., Fox, B.A., Petty, H.R. J. Cell. Physiol. (1994)
- Major histocompatibility complex-restricted antigen receptor on T cells. VIII. Role of the LFA-1 molecule. Golde, W.T., Kappler, J.W., Greenstein, J., Malissen, B., Hood, L., Marrack, P. J. Exp. Med. (1985)
- ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation. Wang, H., McCann, F.E., Gordan, J.D., Wu, X., Raab, M., Malik, T.H., Davis, D.M., Rudd, C.E. J. Exp. Med. (2004)
- Control of leukocyte rolling velocity in TNF-alpha-induced inflammation by LFA-1 and Mac-1. Dunne, J.L., Ballantyne, C.M., Beaudet, A.L., Ley, K. Blood (2002)
- Inhibition of epidermal Langerhans cell function by low dose ultraviolet B radiation. Ultraviolet B radiation selectively modulates ICAM-1 (CD54) expression by murine Langerhans cells. Tang, A., Udey, M.C. J. Immunol. (1991)
- Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance. Emoto, M., Emoto, Y., Brinkmann, V., Miyamoto, M., Yoshizawa, I., Stäber, M., van Rooijen, N., Hamann, A., Kaufmann, S.H. J. Immunol. (2003)
- Regulation of leukocyte function-associated antigen 1-mediated adhesion by somatostatin and substance P in mouse spleen cells. Kang, B.N., Kim, H.J., Jeong, K.S., Park, S.J., Kim, S.H., Kim, S.R., Kim, T.H., Ryu, S.Y. Neuroimmunomodulation (2004)
- Cell-to-Cell adhesion via intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 pathway is involved in 1alpha,25(OH)2D3, PTH and IL-1alpha-induced osteoclast differentiation and bone resorption. Okada, Y., Morimoto, I., Ura, K., Watanabe, K., Eto, S., Kumegawa, M., Raisz, L., Pilbeam, C., Tanaka, Y. Endocr. J. (2002)
- Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways. Xu, B., Wagner, N., Pham, L.N., Magno, V., Shan, Z., Butcher, E.C., Michie, S.A. J. Exp. Med. (2003)
- Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice. Berlin-Rufenach, C., Otto, F., Mathies, M., Westermann, J., Owen, M.J., Hamann, A., Hogg, N. J. Exp. Med. (1999)
- The antigen dose determines T helper subset development by regulation of CD40 ligand. Ruedl, C., Bachmann, M.F., Kopf, M. Eur. J. Immunol. (2000)
- Indefinite survival of neonatal porcine islet xenografts by simultaneous targeting of LFA-1 and CD154 or CD45RB. Rayat, G.R., Gill, R.G. Diabetes (2005)