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Gene Review

CDX4  -  caudal type homeobox 4

Homo sapiens

Synonyms: Caudal-type homeobox protein 4, Homeobox protein CDX-4
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Disease relevance of CDX4

  • We report here that CDX4 is expressed normally in early hematopoietic progenitors and is expressed aberrantly in approximately 25% of acute myeloid leukemia (AML) patient samples [1].
  • Inasmuch as many human leukemias show dysregulated expression of a spectrum of HOX family members, these collective findings also suggest a central role for CDX4 expression in the genesis of acute leukemia [1].

High impact information on CDX4


Biological context of CDX4

  • Structure-function analysis demonstrates that leukemic transformation requires intact Cdx4 transactivation and DNA-binding domains but not the putative Pbx cofactor interaction motif [1].

Anatomical context of CDX4

  • In the amphibian Xenopus laevis the earliest expression of Cdx1, Cdx2 and Cdx4 is within the developing mesoderm [2].

Other interactions of CDX4

  • Localisation of BRX, its human homolog has shown the gene to be located within the orthologous but inverted human CDX4-XIST segment [3].


  1. Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Bansal, D., Scholl, C., Fr??hling, S., McDowell, E., Lee, B.H., D??hner, K., Ernst, P., Davidson, A.J., Daley, G.Q., Zon, L.I., Gilliland, D.G., Huntly, B.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. FGF signal transduction and the regulation of Cdx gene expression. Keenan, I.D., Sharrard, R.M., Isaacs, H.V. Dev. Biol. (2006) [Pubmed]
  3. Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region. Simmler, M.C., Heard, E., Rougeulle, C., Cruaud, C., Weissenbach, J., Avner, P. Mamm. Genome (1997) [Pubmed]
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