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Gene Review

EIF3M  -  eukaryotic translation initiation factor 3...

Homo sapiens

Synonyms: B5, Eukaryotic translation initiation factor 3 subunit M, FLJ29030, Fetal lung protein B5, GA17, ...
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Disease relevance of PCID1

  • The expression of a previously uncharacterized human hfl-B5 cDNA confers susceptibility for herpes simplex virus (HSV) to porcine cells and fulfills criteria as an HSV entry receptor (A. Perez, Q.-X. Li, P. Perez-Romero, G. DeLassus, S. R. Lopez, S. Sutter, N. McLaren, and A. Oveta Fuller, J. Virol. 79:7419-7430, 2005) [1].
  • These results indicate that GA17 was internalized into the glioblastoma cells and that 111In was retained within the cancer cells [2].
  • Neocarzinostatin (NCS) linked to the thiol group on the hinge region of the Fab' fragment of GA-17, a murine monoclonal antibody reacting with tyrosine-specific phosphorylated antigens, which are exclusively expressed on the cell surface of human astrocytomas, was evaluated for in vivo activity [3].
  • One strain, GA-17, identified as Bacteroides thetaiotaomicron, was tested in several locations in Europe with excellent performance in Southern Europe [4].
  • The affinity constant of GA-17 F (ab')2 fragment binding to NCI-H69 was 1.02 x 10(8)/M while that to the glioma cell line U87MG was 1.22 x 10(8)/M [5].

High impact information on PCID1

  • Recombinant protein from a selected clone catalyzed the three-step conversions of GA12 to GA25 and of GA53 to GA17, as well as the formation of the C19-GAs, GA1, GA9, and GA20, from their respective aldehyde precursors, GA23, GA24, and GA19 [6].
  • The gene, designated hfl-B5, encodes a type II cell surface membrane protein, B5, that is broadly expressed in human primary tissue and cell lines [7].
  • Radiolabeled GA-17, a murine monoclonal antibody that reacts specifically with glioma cells, bound to a small-cell lung cancer (SCLC) cell line NCI-H69 derived from neural cells, both in vitro and in vivo [5].
  • In conclusion, the radiolabeled GA-17 F(ab')2 fragment is expected to be useful clinically to visualize the small-cell lung cancer and in radioimmunotherapy [5].
  • Iodine-125-labeled GA-17 F(ab')2 fragments injected i.v. localized well in NCI-H69 cells xenografted in nude mice [5].

Anatomical context of PCID1

  • Two of them (GA-17 and GB-4) reacted exclusively with the membrane of glioma cells, and the other (GC-3) reacted with the membrane of glioma cells and a T cell line (MOLT-4) [8].

Other interactions of PCID1


Analytical, diagnostic and therapeutic context of PCID1

  • The biodistribution study with 125I- and 111In-labeled antibodies showed specific localization of radiolabeled GA17 to the xenografts [10].


  1. The C terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection. Perez-Romero, P., Fuller, A.O. J. Virol. (2005) [Pubmed]
  2. Radioimmunotherapy of human glioma xenografts in nude mice by indium-111 labelled internalising monoclonal antibody. Saga, T., Sakahara, H., Nakamoto, Y., Sato, N., Zhao, S., Aoki, T., Miyatake, S., Namba, Y., Konishi, J. Eur. J. Cancer (1999) [Pubmed]
  3. Antitumour activity of an immunoconjugate composed of anti-human astrocytoma monoclonal antibody and neocarzinostatin. Kondo, S., Nakatsu, S., Sakahara, H., Kobayashi, H., Konishi, J., Namba, Y. Eur. J. Cancer (1993) [Pubmed]
  4. Method for isolation of Bacteroides bacteriophage host strains suitable for tracking sources of fecal pollution in water. Payan, A., Ebdon, J., Taylor, H., Gantzer, C., Ottoson, J., Papageorgiou, G.T., Blanch, A.R., Lucena, F., Jofre, J., Muniesa, M. Appl. Environ. Microbiol. (2005) [Pubmed]
  5. Scintigraphic detection of neural-cell-derived small-cell lung cancer using glioma-specific antibody. Kobayashi, H., Sakahara, H., Hosono, M., Shirato, M., Kondo, S., Miyatake, S., Kikuchi, H., Namba, Y., Endo, K., Konishi, J. J. Cancer Res. Clin. Oncol. (1994) [Pubmed]
  6. Expression cloning of a gibberellin 20-oxidase, a multifunctional enzyme involved in gibberellin biosynthesis. Lange, T., Hedden, P., Graebe, J.E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins. Perez, A., Li, Q.X., Perez-Romero, P., Delassus, G., Lopez, S.R., Sutter, S., McLaren, N., Fuller, A.O. J. Virol. (2005) [Pubmed]
  8. Human glioma-specific antigens detected by monoclonal antibodies. Kondo, S., Miyatake, S., Iwasaki, K., Oda, Y., Kikuchi, H., Zu, Y., Shamoto, M., Namba, Y. Neurosurgery (1992) [Pubmed]
  9. Analysis of the close relationship between human astrocytoma-specific antigens detected by murine monoclonal antibodies and c-kit proto-oncogene product. Kondo, S., Miyatake, S., Matsumoto, M., Nakatsu, S., Iwasaki, K., Oda, Y., Kikuchi, H., Namba, Y. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  10. Detection of altered adhesion molecule expression in experimental tumors by a radiolabeled monoclonal antibody. Saga, T., Sakahara, H., Yao, Z., Nakamoto, Y., Sato, N., Hattori, N., Zhang, M., Zhao, S., Aoki, T., Miyatake, S., Namba, Y., Konishi, J. Jpn. J. Cancer Res. (1997) [Pubmed]
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