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Gene Review

MTX2  -  metaxin 2

Homo sapiens

Synonyms: Metaxin-2, Mitochondrial outer membrane import complex protein 2
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Disease relevance of MTX2

  • Affinity-purified antibodies against metaxin 2 were prepared against the recombinant protein produced in E. coli and were used to analyze the subcellular distribution of metaxin 2 [1].
  • These proteins share 80-90% sequence identity and showed structural similarity to bacterial toxins: mosquitocidal toxin (MTX2) from Bacillus sphaericus and alpha toxin from Clostridium septicum [2].
  • The numbers of drop-outs due to toxicity were SSZ 9, MTX 2, COMBI 5 [3].

High impact information on MTX2


Biological context of MTX2

  • Among overexpressed proteins were heat-shock, structural and membrane proteins and enzymes involved in gene silencing, protein synthesis/degradation, mitochondrial protein import (metaxin 2), detoxification (GST-pi) and energy metabolism [6].

Anatomical context of MTX2

  • In bone marrow cells, the combinations of 5-FU 2 h prior to MTX or MTX 2 h prior to 5-FU followed by a 48 h incubation, respectively, gave growth rates of 79.66 +/- 7.41% (protection) and 31.39 +/- 1.77% of the control rate [7].

Associations of MTX2 with chemical compounds

  • The overall folding of MTX2 consists of three loops stabilized by the four disulfides and forming a two- and a three-stranded beta-sheet [4].
  • The combinations of 5-FU 2 h prior to MTX or MTX 2 h prior to 5-FU followed by a 48 h incubation, respectively, gave growth rates of 20.96 +/- 2.44% and 19.86 +/- 2.56% of the control rate for MCF-7 cells [7].

Analytical, diagnostic and therapeutic context of MTX2

  • Thereafter SR patients received HD-MTX 2 g/m2, a modified protocol II, and continuation therapy with triple intrathecal chemotherapy (TIT); IR patients received protocol Ib, HD-MTX 5 g/m2, protocol II and continuation therapy with TIT; HR patients received 9 polychemotherapy blocks, cranial irradiation and continuation therapy [8].


  1. Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane. Armstrong, L.C., Saenz, A.J., Bornstein, P. J. Cell. Biochem. (1999) [Pubmed]
  2. Molecular cloning, expression, and characterization of novel hemolytic lectins from the mushroom Laetiporus sulphureus, which show homology to bacterial toxins. Tateno, H., Goldstein, I.J. J. Biol. Chem. (2003) [Pubmed]
  3. Combination of sulphasalazine and methotrexate versus the single components in early rheumatoid arthritis: a randomized, controlled, double-blind, 52 week clinical trial. Haagsma, C.J., van Riel, P.L., de Jong, A.J., van de Putte, L.B. Br. J. Rheumatol. (1997) [Pubmed]
  4. Solution structure of a green mamba toxin that activates muscarinic acetylcholine receptors, as studied by nuclear magnetic resonance and molecular modeling. Ségalas, I., Roumestand, C., Zinn-Justin, S., Gilquin, B., Ménez, R., Ménez, A., Toma, F. Biochemistry (1995) [Pubmed]
  5. A particularly labile Asp-Pro bond in the green mamba muscarinic toxin MTX2. Effect of protein conformation on the rate of cleavage. Ségalas, I., Thai, R., Ménez, R., Vita, C. FEBS Lett. (1995) [Pubmed]
  6. Correlation of protein expression, Gleason score and DNA ploidy in prostate cancer. Lexander, H., Palmberg, C., Hellman, U., Auer, G., Hellström, M., Franzén, B., Jörnvall, H., Egevad, L. Proteomics (2006) [Pubmed]
  7. 5-Fluorouracil simultaneously maintains methotrexate antineoplastic activity in human breast cancer and protects against methotrexate cytotoxicity in human bone marrow. Bowen, D., Johnson, D.H., Southerland, W.M., Hughes, D.E., Hawkins, M. Anticancer Res. (1999) [Pubmed]
  8. Intensive BFM chemotherapy for childhood ALL: interim analysis of the AIEOP-ALL 91 study. Associazione Italiana Ematologia Oncologia Pediatrica. Conter, V., Aricò, M., Valsecchi, M.G., Rizzari, C., Testi, A., Miniero, R., Di Tullio, M.T., Lo Nigro, L., Pession, A., Rondelli, R., Messina, C., Santoro, N., Mori, P.G., De Rossi, G., Tamaro, P., Silvestri, D., Biondi, A., Basso, G., Masera, G. Haematologica (1998) [Pubmed]
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