Disease relevance of FARS2

• The crystal structure of the ternary complex of (alphabeta)(2) heterotetrameric phenylalanyl-tRNA synthetase (PheRS) from Thermus thermophilus with cognate tRNA(Phe) and a nonhydrolyzable phenylalanyl-adenylate analogue (PheOH-AMP) has been determined at 3.1 A resolution [1].
• Of 369 registered dentists in Fars province in Iran, 309 (83.7%) responded to a survey regarding knowledge, attitudes, and practices related to human immunodeficiency virus (HIV) infection [2].
• The respiratory and non-respiratory manifestations of human pharyngeal myiasis caused by Oestrus ovis larvae in 33 patients from the Fars province, in southern Iran, are described here [3].
• The experience with 113 patients with Kawasaki disease in Fars Province, Iran [4].
• The prevalence of dental caries in 5 - 18-year-old insulin-dependent diabetics of Fars Province, southern Iran [5].

High impact information on FARS2

• First, the mutations of Leu-202, Ser-211, Asp-234, and Thr-236 made the PheRS incorrectly hydrolyze the cognate Phe-tRNA(Phe), indicating that these residues participate in the Tyr hydroxy group recognition and are responsible for discrimination against Phe [6].
• Comparisons with the sequences of PheRS from yeast and Drosophila mitochondria indicate they are 42 % and 51 % identical with the human mtPheRS, respectively [7].
• Using consensus sequences derived from conserved regions of the alpha and beta-subunits from bacterial PheRS, two partially sequenced cDNA clones were identified [7].
• Our data suggest that the idiosyncratic feature of PheRS, which aminoacylates the 2'-OH group of the terminal ribose, is dictated by the system-specific topology of the CCA end-binding site [1].
• This study was undertaken in Fars Province, southern Iran, to determine the prevalence rates of dental caries in a group of metabolically well-controlled patients with type I diabetes mellitus and in a control group [5].

Biological context of FARS2

• Epidemiology of childhood burn injuries in Fars province, Iran [8].
• Sex ratio at birth in dairy herds in Fars province, southern Iran [9].
• Hospital waste management status in university hospitals of the Fars province, Iran [10].

Associations of FARS2 with chemical compounds

• The functional roles of phenylalanine and ATP in productive binding of the tRNA(Phe) acceptor end have been studied by photoaffinity labeling (cross-linking) of T. thermophilus phenylalanyl-tRNA synthetase (PheRS) with tRNA(Phe) analogs containing the s(4)U residue in different positions of the 3'-terminal single-stranded sequence [11].

References