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Gene Review:

Kazald1 - Kazal-type serine peptidase inhibitor...

Mus musculus

Synonyms: AI842353, Bone and odontoblast-expressed protein 1, Bono1, IGFBP-rP10, IGFBP-related protein 10, ...

Shibata, Y. et al., James, M.J. et al., Kiukkonen, A. et al.

Kiukkonen, Sahlberg, Lukinmaa, Alaluusua, Peltonen, Partanen, James, Järvinen, Thesleff,

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High impact information on Kazald1

As detected by in situ hybridization of tissue sections, localization and intensity of Bono1 and MMP-20 expression showed no definite difference between the control and exposed tooth explants, suggesting that TCDD does not affect their expression [1].
We identified a new member of the IGFBP superfamily, designated IGFBP-rP10, whose expression is up-regulated at the early phase of bone regeneration [2].
These results suggest that IGFBP-rP10 is involved in the proliferation of osteoblasts during bone formation and bone regeneration [2].
A real-time-based RT-PCR analysis demonstrated that various tissues including bone expressed IGFBP-rP10 mRNA in various degrees, and confirmed an up-regulation at the early phase of bone regeneration [2].
Expression was strongly and specifically localised to developing bones and odontoblasts in teeth, therefore we have named this gene Bono1 (Bone and odontoblasts) [3].

Anatomical context of Kazald1

In the tooth, Bono1 was localised in secretory odontoblasts [3].
Bono1: a gene associated with regions of deposition of bone and dentine [3].

References

2,3,7,8-Tetrachlorodibenzo-p-dioxin specifically reduces mRNA for the mineralization-related dentin sialophosphoprotein in cultured mouse embryonic molar teeth. Kiukkonen, A., Sahlberg, C., Lukinmaa, P.L., Alaluusua, S., Peltonen, E., Partanen, A.M. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
Role of a new member of IGFBP superfamily, IGFBP-rP10, in proliferation and differentiation of osteoblastic cells. Shibata, Y., Tsukazaki, T., Hirata, K., Xin, C., Yamaguchi, A. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
Bono1: a gene associated with regions of deposition of bone and dentine. James, M.J., Järvinen, E., Thesleff, I. Gene Expr. Patterns (2004) [Pubmed]

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