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Gene Review

KAZALD1  -  Kazal-type serine peptidase inhibitor...

Homo sapiens

Synonyms: BONO1, FKSG28, FKSG40, IGFBP-rP10, Kazal-type serine protease inhibitor domain-containing protein 1, ...
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Disease relevance of KAZALD1

  • The presence of the linear plasmids lp25 and lp56 of Borrelia burgdorferi B31 was found to dramatically decrease the rate of transformation by electroporation with the shuttle vector pBSV2, an autonomously replicating plasmid that confers kanamycin resistance (P. E. Stewart, R. Thalken, J. L. Bono, and P. Rosa, Mol. Microbiol. 39:714-721, 2001) [1].
  • Seven patients with annuloaortic ectasia were treated according to the method described by Bentall and De Bono [2].
  • Seventy-six chronic alcoholics in Japan were evaluated for histological changes of liver needle biopsies, Chiron C100 antibody (C-100) for hepatitis C virus, as well as clinical and laboratory data [3].
  • Screening children with thrombosis for thrombophilic proteins. Cui bono [4]?

Psychiatry related information on KAZALD1

  • Mental health care for the poor: the Pro Bono Counseling Project [5].
  • Research suggests that the stability of job satisfaction is partially the result of dispositions (J. J. Connolly & C. Viswesvaran, 2000; C. Dormann & D. Zapf, 2001; T. A. Judge & J. E. Bono, 2001a; T. A. Judge, D. Heller, & M. K. Mount, 2002) [6].

High impact information on KAZALD1

  • These data along with previous sequencing of the DC-1 antigen [Bono, M. R., & Strominger, J. L. (1982) Nature (London) 299, 836-838] demonstrate that three distinct subsets of HLA-DR-like antigens are expressed by a homozygous human lymphoblastoid cell line [7].
  • Public health social work: pro bono publico [8].

Analytical, diagnostic and therapeutic context of KAZALD1


  1. Decreased electroporation efficiency in Borrelia burgdorferi containing linear plasmids lp25 and lp56: impact on transformation of infectious B. burgdorferi. Lawrenz, M.B., Kawabata, H., Purser, J.E., Norris, S.J. Infect. Immun. (2002) [Pubmed]
  2. Surgical treatment of annuloaortic estasia: experience in 7 consecutive patients. Koizumi, S., Mohri, H., Kagawa, Y., Saji, K., Haneda, K., Kahata, O., Itoh, T., Yokoyama, A., Ohmi, M., Horiuchi, T. Ann. Thorac. Surg. (1978) [Pubmed]
  3. Clinicopathological analysis of alcoholic liver disease complicating chronic type C hepatitis. Noguchi, O., Yamaoka, K., Ikeda, T., Tozuka, S., Sakamoto, S., Kanayama, M., Uchida, T. Liver (1991) [Pubmed]
  4. Screening children with thrombosis for thrombophilic proteins. Cui bono? Sutor, A.H. J. Thromb. Haemost. (2003) [Pubmed]
  5. Mental health care for the poor: the Pro Bono Counseling Project. Bembry, J.X., Anderson, B.K., Yaggy, E.O. Journal of health care for the poor and underserved. (2002) [Pubmed]
  6. Adaptation-level theory, opponent process theory, and dispositions: an integrated approach to the stability of job satisfaction. Bowling, N.A., Beehr, T.A., Wagner, S.H., Libkuman, T.M. The Journal of applied psychology. (2005) [Pubmed]
  7. A homozygous human cell line contains three subsets of HLA-DR-like antigens distinguishable by amino acid sequencing. Andrews, D.W., Bono, M.R., Strominger, J.L. Biochemistry (1982) [Pubmed]
  8. Public health social work: pro bono publico. Poole, D.L. Health & social work. (1995) [Pubmed]
  9. Meningococcal vaccination: cui bono? Szucs, T.D. PharmacoEconomics. (2005) [Pubmed]
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