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Gene Review

Mmp20  -  matrix metallopeptidase 20 (enamelysin)

Mus musculus

Synonyms: Enamel metalloproteinase, Enamelysin, MMP-20, Matrix metalloproteinase-20
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High impact information on Mmp20


Biological context of Mmp20


Anatomical context of Mmp20


Associations of Mmp20 with chemical compounds

  • Two proteinases have been isolated from the extracellular enamel matrix of developing teeth: enamelysin (MMP-20), a matrix metalloproteinase. and kallikrein-4 (KLK4), a serine proteinase [7].

Other interactions of Mmp20


Analytical, diagnostic and therapeutic context of Mmp20


  1. Enamelysin (matrix metalloproteinase 20)-deficient mice display an amelogenesis imperfecta phenotype. Caterina, J.J., Skobe, Z., Shi, J., Ding, Y., Simmer, J.P., Birkedal-Hansen, H., Bartlett, J.D. J. Biol. Chem. (2002) [Pubmed]
  2. Matrix metalloproteinase inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development. Bourd-Boittin, K., Fridman, R., Fanchon, S., Septier, D., Goldberg, M., Menashi, S. Exp. Cell Res. (2005) [Pubmed]
  3. Origin, splicing, and expression of rodent amelogenin exon 8. Bartlett, J.D., Ball, R.L., Kawai, T., Tye, C.E., Tsuchiya, M., Simmer, J.P. J. Dent. Res. (2006) [Pubmed]
  4. Isolation, characterization, and chromosomal location of the mouse enamelysin gene. Caterina, J., Shi, J., Krakora, S., Bartlett, J.D., Engler, J.A., Kozak, C.A., Birkedal-Hansen, H. Genomics (1999) [Pubmed]
  5. Enamelysin (matrix metalloproteinase-20): localization in the developing tooth and effects of pH and calcium on amelogenin hydrolysis. Fukae, M., Tanabe, T., Uchida, T., Lee, S.K., Ryu, O.H., Murakami, C., Wakida, K., Simmer, J.P., Yamada, Y., Bartlett, J.D. J. Dent. Res. (1998) [Pubmed]
  6. Cloning, characterization, and expression analysis of mouse enamelysin. Caterina, J., Shi, J., Sun, X., Qian, Q., Yamada, S., Liu, Y., Krakora, S., Bartlett, J.D., Yamada, Y., Engler, J.A., Birkedal-Hansen, H., Simmer, J.P. J. Dent. Res. (2000) [Pubmed]
  7. Enamelysin and kallikrein-4 mRNA expression in developing mouse molars. Hu, J.C., Sun, X., Zhang, C., Liu, S., Bartlett, J.D., Simmer, J.P. Eur. J. Oral Sci. (2002) [Pubmed]
  8. 2,3,7,8-Tetrachlorodibenzo-p-dioxin specifically reduces mRNA for the mineralization-related dentin sialophosphoprotein in cultured mouse embryonic molar teeth. Kiukkonen, A., Sahlberg, C., Lukinmaa, P.L., Alaluusua, S., Peltonen, E., Partanen, A.M. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  9. Dentin sialoprotein, dentin phosphoprotein, enamelysin and ameloblastin: tooth-specific molecules that are distinctively expressed during murine dental differentiation. Bègue-Kirn, C., Krebsbach, P.H., Bartlett, J.D., Butler, W.T. Eur. J. Oral Sci. (1998) [Pubmed]
  10. Involvement of matrix metalloproteinases in the onset of dentin mineralization. Fanchon, S., Bourd, K., Septier, D., Everts, V., Beertsen, W., Menashi, S., Goldberg, M. Eur. J. Oral Sci. (2004) [Pubmed]
  11. Formation of the dentino-enamel interface in enamelysin (MMP-20)-deficient mouse incisors. Beniash, E., Skobe, Z., Bartlett, J.D. Eur. J. Oral Sci. (2006) [Pubmed]
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