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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

POP4  -  processing of precursor 4, ribonuclease...

Homo sapiens

Synonyms: RPP29, Ribonuclease P protein subunit p29, hPOP4
 
 
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Disease relevance of POP4

  • Serum levels of hPL, PAPP-A and PP14 in patients with early pregnancy bleeding and subchorionic hemorrhage [1].
  • There was no difference between serum levels of hPL, PAPP-A and PP14 in 29 women with and 40 women without subchorionic hemorrhage, and no correlation between serum levels and the size of the hematoma [1].
 

High impact information on POP4

  • A complete system, consisting of commercially available laser-induced fluorescence capillary electrophoresis (ABI PRISM 310) and performance optimized polymer 4 (POP-4), was evaluated for microsatellite separations [2].
  • POP-4 is a low viscosity polymer for use in uncoated fused microbore silica capillaries [2].
  • We show that dye-specific mobility anomalies exist for 5'-fluorophor-labelled single-stranded DNA (ssDNA) fragments in CE using the performance-optimized polymer 4 (POP4) buffer sieving matrix, containing the entangled poly(N,N-dimethylacrylamide) polymer, urea, and 2-pyrrolidinone [3].
  • Comparison of the calculated numbers of CAG repeats in the HD gene using this sequence-specific DNA standard with a commercially available standard (GENESCAN-500 TAMRA) showed that the latter underestimated the number of CAG repeats by three when analyzed by capillary electrophoresis on the ABI 310 Genetic Analyzer (POP4 polymer) [4].
  • Serum levels of human placental lactogen, pregnancy-associated plasma protein A and endometrial secretory protein PP14 in first trimester of diabetic pregnancy [5].
 

Analytical, diagnostic and therapeutic context of POP4

  • TRAP/PCR products were generated using a fluorescent 4,7,2'4'5'7',-hexachloro-6-carboxyfluorescein(HEX)-labeled TS primer and analyzed on the Applied Biosystems Model 310 CE system using POP4 polymer [6].

References

  1. Serum levels of hPL, PAPP-A and PP14 in patients with early pregnancy bleeding and subchorionic hemorrhage. Pedersen, J.F., Ruge, S., Sørensen, S. Acta obstetricia et gynecologica Scandinavica. (1995) [Pubmed]
  2. High-precision genotyping by denaturing capillary electrophoresis. Wenz, H., Robertson, J.M., Menchen, S., Oaks, F., Demorest, D.M., Scheibler, D., Rosenblum, B.B., Wike, C., Gilbert, D.A., Efcavitch, J.W. Genome Res. (1998) [Pubmed]
  3. Influence of fluorophor dye labels on the migration behavior of polymerase chain reaction--amplified short tandem repeats during denaturing capillary electrophoresis. Hahn, M., Wilhelm, J., Pingoud, A. Electrophoresis (2001) [Pubmed]
  4. Accurate determination of the number of CAG repeats in the Huntington disease gene using a sequence-specific internal DNA standard. Bruland, O., Almqvist, E.W., Goldberg, Y.P., Boman, H., Hayden, M.R., Knappskog, P.M. Clin. Genet. (1999) [Pubmed]
  5. Serum levels of human placental lactogen, pregnancy-associated plasma protein A and endometrial secretory protein PP14 in first trimester of diabetic pregnancy. Pedersen, J.F., Sørensen, S., Mølsted-Pedersen, L. Acta obstetricia et gynecologica Scandinavica. (1998) [Pubmed]
  6. High-throughput analysis of telomerase by capillary electrophoresis. Atha, D.H., Miller, K., Sanow, A.D., Xu, J., Hess, J.L., Wu, O.C., Wang, W., Srivastava, S., Highsmith, W.E. Electrophoresis (2003) [Pubmed]
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