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Cdc20  -  cell division cycle 20

Mus musculus

Synonyms: 2310042N09Rik, C87100, Cell division cycle protein 20 homolog, mmCdc20, p55CDC
 
 
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High impact information on Cdc20

  • Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20 [1].
  • Similar results were obtained using dominant-negative forms of Mad2 and BubR1, as well as checkpoint resistant dominant APC/C activating forms of Cdc20 [2].
  • In support of this, microarray-based gene expression analysis showed that induction of expression of the cell division cycle 20 gene (Cdc20), a key regulator of the mitotic anaphase-promoting complex, is significantly reduced in Egr-1 null mice [3].
  • To define the role of p55CDC during the mammalian cell cycle, we overexpressed this protein in the murine myeloid cell line 32Dcl3 [4].
  • Our work suggests that p55CDC participates in cell growth, maturation, and death [4].
 

Biological context of Cdc20

References

  1. Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20. Shoji, S., Yoshida, N., Amanai, M., Ohgishi, M., Fukui, T., Fujimoto, S., Nakano, Y., Kajikawa, E., Perry, A.C. EMBO J. (2006) [Pubmed]
  2. The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes. Tsurumi, C., Hoffmann, S., Geley, S., Graeser, R., Polanski, Z. J. Cell Biol. (2004) [Pubmed]
  3. Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice. Liao, Y., Shikapwashya, O.N., Shteyer, E., Dieckgraefe, B.K., Hruz, P.W., Rudnick, D.A. J. Biol. Chem. (2004) [Pubmed]
  4. The role of p55CDC in cell cycle control and mammalian cell proliferation, differentiation, and apoptosis. Lin, M., Chang, J.K., Shankar, D., Sakamoto, K.M. Exp. Mol. Pathol. (2003) [Pubmed]
  5. Megakaryocyte polyploidization is associated with decreased expression of polo-like kinase (PLK). Yagi, M., Roth, G.J. J. Thromb. Haemost. (2006) [Pubmed]
 
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