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Gene Review

Tg(Tek-cre)12Flv  -  transgene insertion 12, Richard A Flavell

Mus musculus

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Disease relevance of Tg(Tek-cre)12Flv


High impact information on Tg(Tek-cre)12Flv


Biological context of Tg(Tek-cre)12Flv


Other interactions of Tg(Tek-cre)12Flv

  • Here, we show that Tie2-Cre-mediated deletion of Nf1 also leads to excision of Nf1 in the hematopoietic lineage [1].

Analytical, diagnostic and therapeutic context of Tg(Tek-cre)12Flv


  1. Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia. Gitler, A.D., Kong, Y., Choi, J.K., Zhu, Y., Pear, W.S., Epstein, J.A. Pediatr. Res. (2004) [Pubmed]
  2. Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. Braren, R., Hu, H., Kim, Y.H., Beggs, H.E., Reichardt, L.F., Wang, R. J. Cell Biol. (2006) [Pubmed]
  3. Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenance. Shimoda, M., Mmanywa, F., Joshi, S.K., Li, T., Miyake, K., Pihkala, J., Abbas, J.A., Koni, P.A. J. Immunol. (2006) [Pubmed]
  4. Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Kisanuki, Y.Y., Hammer, R.E., Miyazaki , J., Williams, S.C., Richardson, J.A., Yanagisawa, M. Dev. Biol. (2001) [Pubmed]
  5. Endothelial cell-specific expression of Cre recombinase in transgenic mice. Li, W.L., Cheng, X., Tan, X.H., Zhang, J.S., Sun, Y.S., Chen, L., Yang, X. Yi Chuan Xue Bao (2005) [Pubmed]
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