High impact information on BLCAP

• Bladder cancer-associated nuclear matrix proteins [1].
• In further categorizing the telomerase activity using 75% of the normalized value in the controls as a cutoff point, we found a significantly increased risk for bladder cancer associated with higher induced telomerase activity (adjusted odds ratio, 3.62; 95% confidence interval, 1.38-9.51) [2].
• A bioinformatic screen for novel A-I RNA editing sites reveals recoding editing in BC10 [3].
• NNAT lies within the singular 8.5-kb intron of the gene encoding bladder cancer-associated protein (BLCAP), which, as we demonstrate, is not imprinted [4].
• BLCAP expression in HeLa cells leads to growth arrest and significantly enhanced apoptosis in vitro and reduced tumor formation in vivo [5].

Biological context of BLCAP

• Thus, BLCAP might be a potential tumor suppressor gene in cervical carcinoma [5].
• The HeLa cells expressing BLCAP show reduced cell growth and clone genicity compared to the vector-transfected cognate cells [5].

Anatomical context of BLCAP

• Previously described natural brominated compounds (BC-1, BC-2, BC-3, BC-10, BC-11, MHC-1) and anthropogenic brominated diphenyl ethers (BDE-47, BDE-99, BDE-100, BDE-154) were detected in a sample of human milk [6].
• Strong labelling with BC10 and TN2 was seen below the epithelium, in electron lucent spaces where the hemidesmosomes were absent, in the fibrotic pannus, in parts of Bowman's layer, the stroma, and Descemet's membrane [7].

References