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Gene Review

NNAT  -  neuronatin

Homo sapiens

Synonyms: Neuronatin, Peg5
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Disease relevance of NNAT


High impact information on NNAT


Biological context of NNAT


Anatomical context of NNAT


Associations of NNAT with chemical compounds


Other interactions of NNAT

  • NNAT lies within the singular 8.5-kb intron of the gene encoding bladder cancer-associated protein (BLCAP), which, as we demonstrate, is not imprinted [5].
  • CONCLUSION: This is the first report on the imprinting status of SLC38A4, NAP1L5, and on the expression patterns of the two transcripts of NNAT in cattle [6].
  • Results suggest that the NNAT scores have use for fair assessment of White and minority children [10].

Analytical, diagnostic and therapeutic context of NNAT


  1. Hypermethylation of the imprinted NNAT locus occurs frequently in pediatric acute leukemia. Kuerbitz, S.J., Pahys, J., Wilson, A., Compitello, N., Gray, T.A. Carcinogenesis (2002) [Pubmed]
  2. cDNA cloning and mRNA expression analysis of the human neuronatin. High level expression in human pituitary gland and pituitary adenomas. Usui, H., Morii, K., Tanaka, R., Tamura, T., Washiyama, K., Ichikawa, T., Kumanishi, T. J. Mol. Neurosci. (1997) [Pubmed]
  3. Loss of neuronatin expression is associated with promoter hypermethylation in pituitary adenoma. Revill, K., Dudley, K.J., Clayton, R.N., McNicol, A.M., Farrell, W.E. Endocr. Relat. Cancer (2009) [Pubmed]
  4. Imprinted expression of neuronatin from modified BAC transgenes reveals regulation by distinct and distant enhancers. John, R.M., Aparicio, S.A., Ainscough, J.F., Arney, K.L., Khosla, S., Hawker, K., Hilton, K.J., Barton, S.C., Surani, M.A. Dev. Biol. (2001) [Pubmed]
  5. The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2. Evans, H.K., Wylie, A.A., Murphy, S.K., Jirtle, R.L. Genomics (2001) [Pubmed]
  6. Assessment of genomic imprinting of SLC38A4, NNAT, NAP1L5, and H19 in cattle. Zaitoun, I., Khatib, H. BMC Genet. (2006) [Pubmed]
  7. Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. Dannenberg, L.O., Edenberg, H.J. BMC Genomics (2006) [Pubmed]
  8. Cloning of human neuronatin gene and its localization to chromosome-20q 11.2-12: the deduced protein is a novel "proteolipid'. Dou, D., Joseph, R. Brain Res. (1996) [Pubmed]
  9. Structure and organization of the human neuronatin gene. Dou, D., Joseph, R. Genomics (1996) [Pubmed]
  10. Comparison of white, African American, Hispanic, and Asian children on the Naglieri Nonverbal Ability Test. Naglieri, J.A., Ronning, M.E. Psychological assessment. (2000) [Pubmed]
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