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MeSH Review

Descemet Membrane

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Disease relevance of Descemet Membrane


High impact information on Descemet Membrane


Chemical compound and disease context of Descemet Membrane


Biological context of Descemet Membrane


Anatomical context of Descemet Membrane


Associations of Descemet Membrane with chemical compounds


Gene context of Descemet Membrane

  • The Descemet's membrane detachment demonstrated the weak adhesion of the stroma and the Descemet's membrane, probably resulting from a dysfunction of the TGFBI protein caused by the mutation of the TGFBIgene [20].
  • Similar requirements were observed for release of endogenous bFGF stored in Descemet's membrane and of exogenous bFGF sequestered by the subendothelial ECM [21].
  • Four of the patients with pathologic myopia had corneal dystrophy that was bilaterally manifest as white opacities in the posterior stroma near Descemet's membrane in an axial distribution; 1 of these 4 patients also had a tilted disc [22].
  • The arrays lie parallel to the corneal surface and are distributed in the extracellular matrix between Bowman's layer and Descemet's membrane [23].
  • There was no detectable Fn in intact, nonwounded control or intact A-corneas, except for Descemet's membrane [24].

Analytical, diagnostic and therapeutic context of Descemet Membrane


  1. Descemet's membrane detachment by sodium hyaluronate. Hoover, D.L., Giangiacomo, J., Benson, R.L. Arch. Ophthalmol. (1985) [Pubmed]
  2. Chalcosis in the human eye. A clinicopathologic study. Rao, N.A., Tso, M.O., Rosenthal, A.R. Arch. Ophthalmol. (1976) [Pubmed]
  3. Increased corneal scarring after phototherapeutic keratectomy in Fuchs' corneal dystrophy. Alaa, M., Waring, G.O., Malaty, A., Grossniklaus, H. Journal of refractive surgery (Thorofare, N.J. : 1995) (1997) [Pubmed]
  4. Dr. P. Siva Reddy Oration. Diabetic keratopathy. Rao, G.N. Indian journal of ophthalmology. (1987) [Pubmed]
  5. Fuchs corneal dystrophy: aberrant collagen distribution in an L450W mutant of the COL8A2 gene. Gottsch, J.D., Zhang, C., Sundin, O.H., Bell, W.R., Stark, W.J., Green, W.R. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  6. Identification of novel mutations in the carbohydrate sulfotransferase gene (CHST6) causing macular corneal dystrophy. El-Ashry, M.F., Abd El-Aziz, M.M., Wilkins, S., Cheetham, M.E., Wilkie, S.E., Hardcastle, A.J., Halford, S., Bayoumi, A.Y., Ficker, L.A., Tuft, S., Bhattacharya, S.S., Ebenezer, N.D. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  7. Long-term observation of morphologic and functional features of cat corneal endothelium after wounding. Bourne, W.M., Nelson, L.R., Buller, C.R., Huang, P.T., Geroski, D.H., Edelhauser, H.F. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  8. Corneal endothelial modulation: a factor released by leukocytes induces basic fibroblast growth factor that modulates cell shape and collagen. Kay, E.P., Gu, X., Ninomiya, Y., Smith, R.E. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
  9. Factors controlling oxygen tension under a hydrogel contact lens. Polse, K.A. Journal of the American Optometric Association. (1981) [Pubmed]
  10. Corneal glycoconjugates: an ultrastructural lectin-gold study. Lawrenson, J.G., Reid, A.R., Allt, G. Histochem. J. (1998) [Pubmed]
  11. Apolipoprotein A-I and B distribution in the human cornea. Ashraf, F., Cogan, D.G., Kruth, H.S. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
  12. Possible role of the vitamin E solubilizer in topical diclofenac on matrix metalloproteinase expression in corneal melting: an analysis of postoperative keratolysis. Hargrave, S.L., Jung, J.C., Fini, M.E., Gelender, H., Cather, C., Guidera, A., Udell, I., Fisher, S., Jester, J.V., Bowman, R.W., McCulley, J.P., Cavanagh, H.D. Ophthalmology (2002) [Pubmed]
  13. Sulfur hexafluoride injection for Descemet's membrane detachment in cataract surgery. Kremer, I., Stiebel, H., Yassur, Y., Weinberger, D. Journal of cataract and refractive surgery. (1997) [Pubmed]
  14. Low levels of inorganic mercury damage the corneal endothelium. Sillman, A.J., Weidner, W.J. Exp. Eye Res. (1993) [Pubmed]
  15. Distribution of fibronectin in human and rabbit corneas. Tervo, T., Sulonen, J., Valtones, S., Vannas, A., Virtanen, I. Exp. Eye Res. (1986) [Pubmed]
  16. Extensive detachment of Descemet membrane after holmium laser sclerostomy. Bergsma, D.R., McCaa, C.S. Ophthalmology (1996) [Pubmed]
  17. Ultrastructural localization of sulfated and unsulfated keratan sulfate in normal and macular corneal dystrophy type I. Lewis, D., Davies, Y., Nieduszynski, I.A., Lawrence, F., Quantock, A.J., Bonshek, R., Fullwood, N.J. Glycobiology (2000) [Pubmed]
  18. Repair of late Descemet's membrane detachment with perfluoropropane gas. Shah, M., Bathia, J., Kothari, K. Journal of cataract and refractive surgery. (2003) [Pubmed]
  19. Mature bovine Descemet's membrane contains desmosine and isodesmosine. Heathcote, J.G., Eyre, D.R., Gross, J. Biochem. Biophys. Res. Commun. (1982) [Pubmed]
  20. Triple anterior chamber after full-thickness lamellar keratoplasty for lattice corneal dystrophy. Hirano, K., Kojima, T., Nakamura, M., Hotta, Y. Cornea (2001) [Pubmed]
  21. Heparanase activity expressed by platelets, neutrophils, and lymphoma cells releases active fibroblast growth factor from extracellular matrix. Ishai-Michaeli, R., Eldor, A., Vlodavsky, I. Cell Regul. (1990) [Pubmed]
  22. Familial pathologic myopia, corneal dystrophy, and deafness: a new syndrome. Kurt, E., Günen, A., Sadikoğlu, Y., Oztürk, F., Tarhan, S., Sari, R.A., Fistik, T., Ari, Z. Jpn. J. Ophthalmol. (2001) [Pubmed]
  23. A large-scale, orthogonal network of microfibril bundles in the corneal stroma. Bruns, R.R., Press, W., Gross, J. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  24. Fibronectin and corneal epithelial wound healing in the vitamin A-deficient rat. Frangieh, G.T., Hayashi, K., Teekhasaenee, C., Wolf, G., Colvin, R.B., Gipson, I.K., Kenyon, K.R. Arch. Ophthalmol. (1989) [Pubmed]
  25. Repopulation of denuded murine Descemet's membrane with life-extended murine corneal endothelial cells as a model for corneal cell transplantation. Joo, C.K., Green, W.R., Pepose, J.S., Fleming, T.P. Graefes Arch. Clin. Exp. Ophthalmol. (2000) [Pubmed]
  26. Stripping of Descemet's membrane: a clinicopathologic correlation. Pieramici, D., Green, W.R., Stark, W.J. Ophthalmic surgery. (1994) [Pubmed]
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