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Gene Review

Grik4  -  glutamate receptor, ionotropic, kainate 4

Mus musculus

Synonyms: 6330551K01Rik, GluK4, GluRgamma1, Glutamate receptor ionotropic, kainate 4, KA-1, ...
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High impact information on Grik4


Anatomical context of Grik4

  • In the adult brain, KA1-Cre transgene expression was restricted mainly to hippocampal CA3 pyramidal and dentate gyrus granule cells, an adult expression pattern characteristic for the endogenous KA1 alleles [3].

Analytical, diagnostic and therapeutic context of Grik4

  • Activity of the KA1 gene promoter during brain development was visualized by Cre immunohistochemistry, and by X-gal staining of beta-galactosidase induced by Cre recombinase in double transgenic KA1-Cre/lacZ indicator mice [3].


  1. Mice with very low expression of the vesicular monoamine transporter 2 gene survive into adulthood: potential mouse model for parkinsonism. Mooslehner, K.A., Chan, P.M., Xu, W., Liu, L., Smadja, C., Humby, T., Allen, N.D., Wilkinson, L.S., Emson, P.C. Mol. Cell. Biol. (2001) [Pubmed]
  2. Spatial distribution of kainate receptor subunit mRNA in the mouse basal ganglia and ventral mesencephalon. Bischoff, S., Barhanin, J., Bettler, B., Mulle, C., Heinemann, S. J. Comp. Neurol. (1997) [Pubmed]
  3. Developmental profile of kainate receptor subunit KA1 revealed by Cre expression in YAC transgenic mice. Kask, K., Jerecic, J., Zamanillo, D., Wilbertz, J., Sprengel, R., Seeburg, P.H. Brain Res. (2000) [Pubmed]
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