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Gene Review

zwf  -  glucose-6-phosphate 1-dehydrogenase

Nostoc sp. PCC 7120

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Disease relevance of zwf


High impact information on zwf

  • They can be found at low frequencies in dense cultures experiencing low light or phosphate limitation, but also form at high frequencies in a zwf mutant strain of Nostoc punctiforme following dark incubation in the presence of fructose [3].
  • Inactivation of opcA yielded a growth phenotype identical to that of the zwf mutant, including a 98% decrease, relative to the wild type, in apparent G6PD specific activity [4].
  • The gene (zwf) encoding glucose-6-phosphate dehydrogenase (G6PD), the initial enzyme of the oxidative pentose phosphate pathway, was inactivated in the heterocyst-forming, facultatively heterotrophic cyanobacterium, Nostoc sp. strain ATCC 29133 [4].
  • The zwf mutant strain had less than 5% of the wild-type apparent G6PD activity, while retaining wild-type rates of photoautotrophic growth with NH4+ and of dark O2 uptake, but it failed to grow either under N2-fixing conditions or in the dark with organic carbon sources [4].
  • This phenotypic and genetic evidence showing near-synchronous induction of dark-induced zwf akinetes indicates that this system will provide a valuable tool for the molecular genetic study of akinete development in N. punctiforme [5].

Associations of zwf with chemical compounds

  • The presence in both strains of a gene fbp, encoding fructose-1,6-bisphosphatase, upstream from zwf strongly suggests that the oxidative pentose phosphate pathway in these organisms may function to completely oxidize glucose 6-phosphate to CO2 [2].
  • Comparison of cyanobacterial zwf sequences revealed the presence of two absolutely conserved cysteine residues which may be implicated in the light/dark control of enzyme activity [2].
  • Upon dark incubation in the presence of fructose, the zwf(-) strain ceased growth and differentiated into akinete-like cells, whereas the wild-type strain exhibited heterotrophic growth [5].
  • A system in which to study the development and genetic regulation of akinetes was investigated using a zwf mutant lacking glucose-6-phosphate dehydrogenase, the initial enzyme of the oxidative pentose phosphate pathway [5].

Analytical, diagnostic and therapeutic context of zwf

  • Transcription of the avaK akinete marker gene was strongly induced in developing zwf akinetes as shown by Northern blotting and green fluorescent protein transcriptional reporter fusions [5].
  • Dark-induced zwf akinetes exhibited increased resistance to the environmental stresses of desiccation, cold, or treatment with lysozyme relative to vegetative cells of both strains [5].


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