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Gene Review

Lyve1  -  lymphatic vessel endothelial hyaluronan...

Mus musculus

Synonyms: 1200012G08Rik, CRSBP-1, Cell surface retention sequence-binding protein 1, Crsbp-1, Crsbp1, ...
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Disease relevance of Xlkd1

  • In simian sarcoma virus-transformed NIH 3T3 cells (SSV-NIH 3T3 cells), a fraction of CRSBP-1 was demonstrated at the cell surface and underwent internalization/recycling as revealed by cell surface 125I labeling and its resistance/sensitivity to trypsin digestion [1].

High impact information on Xlkd1


Biological context of Xlkd1

  • The cell surface retention sequence (CRS) binding protein-1 (CRSBP-1) is a newly identified membrane glycoprotein which is hypothesized to be responsible for cell surface retention of the oncogene v-sis and c-sis gene products and other secretory proteins containing CRSs [1].

Anatomical context of Xlkd1

  • In normal and other transformed NIH 3T3 cells, CRSBP-1 was relatively stable and did not undergo rapid turnover and internalization/recycling at the cell surface [1].


  1. Cell surface retention sequence binding protein-1 interacts with the v-sis gene product and platelet-derived growth factor beta-type receptor in simian sarcoma virus-transformed cells. Boensch, C., Huang, S.S., Connolly, D.T., Huang, J.S. J. Biol. Chem. (1999) [Pubmed]
  2. Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action. Cao, R., Björndahl, M.A., Gallego, M.I., Chen, S., Religa, P., Hansen, A.J., Cao, Y. Blood (2006) [Pubmed]
  3. Induction of lymphatic endothelial cell differentiation in embryoid bodies. Liersch, R., Nay, F., Lu, L., Detmar, M. Blood (2006) [Pubmed]
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