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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, sis

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Disease relevance of Genes, sis


High impact information on Genes, sis


Biological context of Genes, sis


Anatomical context of Genes, sis

  • Expression and developmental control of platelet-derived growth factor A-chain and B-chain/Sis genes in rat aortic smooth muscle cells [14].
  • CD44 protein levels and its biological activity are regulated in Balb/c 3T3 fibroblasts by serum factors and by transformation with the ras but not with the sis oncogene [15].
  • CD44s (standard isoform) levels and hyaluronan-binding activity were investigated in Balb/c 3T3 cells and their derivatives transformed with ras or sis oncogenes as a function of serum concentration in the medium [15].
  • In many tumor cell lines, including some transformed by the ras and sis oncogenes, activation of protein kinase A by elevation of cyclic AMP or activation of protein kinase C by addition of phorbol esters can restore many normal aspects of growth and morphology [16].
  • The first component, which eluted at 0.8 M NaCl, is able to induce autophosphorylation of the platelet-derived growth factor (PDGF) receptor, is a mitogen for Swiss 3T3 cells and corresponds to the PDGF B chain product of the v-sis oncogene [17].

Associations of Genes, sis with chemical compounds


Gene context of Genes, sis

  • DFSP and GCF tumors are genetically characterized by chromosomal rearrangements fusing the collagen type Ialpha1 (COLIA1) gene to the platelet-derived growth factor B-chain (PDGFB) gene [22].
  • The v-sis oncogene encodes a protein structurally and functionally related to human platelet-derived growth factor (PDGF) [12].
  • All three SSV-transformed cells secreted v-sis gene product (p44). p44 was secreted but remained tightly associated with the cell surface [23].
  • The results showed that when complemented either by a ras oncogene expressed at a somewhat enhanced level or by the v-sis oncogene, v-fes can supply the additional change required for malignant transformation [24].
  • Because these responses play key roles in lung injury, PDGF-B (c-sis) gene expression was measured by Northern blot analysis of lung total RNA prepared after oxidant injury was induced by chronic exposure of rats to 85% oxygen for zero, 1, 3, and 7 days [25].

Analytical, diagnostic and therapeutic context of Genes, sis


  1. Mechanism of action and in vivo role of platelet-derived growth factor. Heldin, C.H., Westermark, B. Physiol. Rev. (1999) [Pubmed]
  2. PDGF B mRNA variants in human tumors with similarity to the v-sis oncogene: expression of cellular PDGF B protein is associated with exon 1 divergence, but not with a 3'UTR splice variant. Heller, S., Scheibenpflug, L., Westermark, B., Nistér, M. Int. J. Cancer (2000) [Pubmed]
  3. Growth factors and oncogenes in human malignant glioma. Westermark, B., Nister, M., Heldin, C.H. Neurologic clinics. (1985) [Pubmed]
  4. Gene mutation analysis in five cases of dermatofibrosarcoma protuberans using formalin-fixed, paraffin-embedded tissues. Saeki, H., Tsunemi, Y., Ohtsuki, M., Kikuchi, K., Tamaki, K. Acta Derm. Venereol. (2005) [Pubmed]
  5. Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Beckmann, M.P., Betsholtz, C., Heldin, C.H., Westermark, B., Di Marco, E., Di Fiore, P.P., Robbins, K.C., Aaronson, S.A. Science (1988) [Pubmed]
  6. Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells. Keating, M.T., Williams, L.T. Science (1988) [Pubmed]
  7. The role of individual cysteine residues in the structure and function of the v-sis gene product. Giese, N.A., Robbins, K.C., Aaronson, S.A. Science (1987) [Pubmed]
  8. Autocrine stimulation by the v-sis gene product requires a ligand-receptor interaction at the cell surface. Hannink, M., Donoghue, D.J. J. Cell Biol. (1988) [Pubmed]
  9. Expression of the PDGF-related transforming protein of simian sarcoma virus in E. coli. Devare, S.G., Shatzman, A., Robbins, K.C., Rosenberg, M., Aaronson, S.A. Cell (1984) [Pubmed]
  10. Deletions in the C-terminal coding region of the v-sis gene: dimerization is required for transformation. Hannink, M., Sauer, M.K., Donoghue, D.J. Mol. Cell. Biol. (1986) [Pubmed]
  11. Tumorigenicity and oncogene expression in pediatric cancers. Pasquale, S.R., Jones, G.R., Doersen, C.J., Weissman, B.E. Cancer Res. (1988) [Pubmed]
  12. Detection of PDGF-2 homodimers in human tumor cells. Igarashi, H., Rao, C.D., Siroff, M., Leal, F., Robbins, K.C., Aaronson, S.A. Oncogene (1987) [Pubmed]
  13. Delivery of FGF genes to wound repair cells enhances arteriogenesis and myogenesis in skeletal muscle. Doukas, J., Blease, K., Craig, D., Ma, C., Chandler, L.A., Sosnowski, B.A., Pierce, G.F. Mol. Ther. (2002) [Pubmed]
  14. Expression and developmental control of platelet-derived growth factor A-chain and B-chain/Sis genes in rat aortic smooth muscle cells. Majesky, M.W., Benditt, E.P., Schwartz, S.M. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  15. CD44 protein levels and its biological activity are regulated in Balb/c 3T3 fibroblasts by serum factors and by transformation with the ras but not with the sis oncogene. Kogerman, P., Sy, M.S., Culp, L.A. J. Cell. Physiol. (1996) [Pubmed]
  16. Cellular signal transduction and the reversal of malignancy. Lockwood, A.H., Murphy, S.K., Borislow, S., Lazarus, A., Pendergast, M. J. Cell. Biochem. (1987) [Pubmed]
  17. Basic fibroblast-like growth factor is present in the conditioned medium of simian sarcoma virus transformed NRK cells. Hicks, K., Friedman, B., Rosner, M.R. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  18. Cell surface expression of membrane-anchored v-sis gene products: glycosylation is not required for cell surface transport. Hannink, M., Donoghue, D.J. J. Cell Biol. (1986) [Pubmed]
  19. Identification of nonessential disulfide bonds and altered conformations in the v-sis protein, a homolog of the B chain of platelet-derived growth factor. Sauer, M.K., Donoghue, D.J. Mol. Cell. Biol. (1988) [Pubmed]
  20. Cell surface retention sequence binding protein-1 interacts with the v-sis gene product and platelet-derived growth factor beta-type receptor in simian sarcoma virus-transformed cells. Boensch, C., Huang, S.S., Connolly, D.T., Huang, J.S. J. Biol. Chem. (1999) [Pubmed]
  21. Cloning, expression, characterization, and role in autocrine cell growth of cell surface retention sequence binding protein-1. Huang, S.S., Tang, F.M., Huang, Y.H., Liu, I.H., Hsu, S.C., Chen, S.T., Huang, J.S. J. Biol. Chem. (2003) [Pubmed]
  22. Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis. Sjöblom, T., Shimizu, A., O'Brien, K.P., Pietras, K., Dal Cin, P., Buchdunger, E., Dumanski, J.P., Ostman, A., Heldin, C.H. Cancer Res. (2001) [Pubmed]
  23. Intracellular turnover, novel secretion, and mitogenically active intracellular forms of v-sis gene product in simian sarcoma virus-transformed cells. Implications for intracellular loop autocrine transformation. Lokeshwar, V.B., Huang, S.S., Huang, J.S. J. Biol. Chem. (1990) [Pubmed]
  24. Malignant transformation of human fibroblast strain MSU-1.1 by v-fes requires an additional genetic change. Lin, C., Maher, V.M., McCormick, J.J. Int. J. Cancer (1995) [Pubmed]
  25. Increased expression of PDGF-B (c-sis) mRNA in rat lung precedes DNA synthesis and tissue repair during chronic hyperoxia. Fabisiak, J.P., Evans, J.N., Kelley, J. Am. J. Respir. Cell Mol. Biol. (1989) [Pubmed]
  26. Translocation of c-abl oncogene and PDGFB (c-sis) gene in a case of CML with 46,XY, t(22;22). Gradl, G., Tesch, H., Schwieder, G., Wagner, T., Fonatsch, C. Blut (1989) [Pubmed]
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