Disease relevance of THEM4

• Thus, epigenetic downregulation of CTMP transcription is a common aberration in glioblastomas [1].
• However, CTMP mRNA expression was lower by at least 50% relative to non-neoplastic brain tissue in 37 (40%) glioblastomas and six (67%) glioma cell lines [1].

High impact information on THEM4

• Moreover, CTMP expression reverts the phenotype of v-Akt-transformed cells examined under a number of criteria including cell morphology, growth rate, and in vivo tumorigenesis [2].
• Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane [2].
• The results with all tested acetal derivatives (Fpmp, Ctmp, Cee, THP) were much less successful due to some accompanying cleavage of internucleotidic H-phosphonate functions during removal of 5'-O-protection (DMT) [3].
• Solid phase synthesis of oligoribonucleotides using the 1-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl (Ctmp) group for the protection of the 2'-hydroxy functions and the H-phosphonate approach [4].
• We have further studied sequence alterations of PTEN (n = 34 FCD(IIb)) and CTMP (n = 20 FCD(IIb)) by laser microdissection/single-strand conformation polymorphism analysis [5].

Chemical compound and disease context of THEM4

• Furthermore, treatment of CTMP-hypermethylated A172 glioma cells with the demethylating agent 5-aza-2'-deoxycytidine and the histone deacetylase inhibitor trichostatin A resulted in partial demethylation of the CTMP promoter and increased CTMP mRNA expression [1].

Biological context of THEM4

• Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias [5].

Associations of THEM4 with chemical compounds

• The radicalization of unbleached lignocellulosic fibers obtained from thermomechanical (TMP) and chemothermomechanical (CTMP) pulps was performed in heterogeneous phase by reaction with dioxygen in the presence of N,N'-ethylenebis(salicylideneiminato)cobalt(II), [Co(salen)], as catalyst [6].
• The presence of galacturonan on the surface of TMP and CTMP was further confirmed by immunogold localization [7].

Other interactions of THEM4

• The carboxyl-terminal modulator protein (CTMP) has been identified as a negative regulator of protein kinase B/Akt [1].

References