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Gene Review

Rheb  -  Ras homolog enriched in brain ortholog (H....

Drosophila melanogaster

Synonyms: CG1081, DReb, Dm Rheb, DmRheb, Dmel\CG1081, ...
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High impact information on Rheb


Biological context of Rheb

  • Here, we show that signaling through TOR and its upstream regulators PI3K and Rheb is necessary and sufficient to suppress starvation-induced autophagy in the Drosophila fat body [4].
  • Overexpression of dRheb in the developing fly (using the GAL4:UAS system) causes dramatic overgrowth of multiple tissues: in the wing, this is due to an increase in cell size; in cultured cells, dRheb overexpression results in accumulation of cells in S phase and an increase in cell size [5].
  • In a screen to identify genes affecting hindgut morphogenesis in Drosophila, we identified a P-element insertion in dRheb, a novel, highly conserved member of the Ras superfamily of G-proteins [5].
  • In Drosophila, we find that overexpression of Drosophila Rheb (dRheb) in S2 cells causes their accumulation in S phase and an increase in cell size [6].
  • Overexpression of dRheb results in increased cell and tissue size without an increase in cell number; reduction of dRheb function results in reduced cell and tissue size [6].

Anatomical context of Rheb


  1. Rheb promotes cell growth as a component of the insulin/TOR signalling network. Saucedo, L.J., Gao, X., Chiarelli, D.A., Li, L., Pan, D., Edgar, B.A. Nat. Cell Biol. (2003) [Pubmed]
  2. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Stocker, H., Radimerski, T., Schindelholz, B., Wittwer, F., Belawat, P., Daram, P., Breuer, S., Thomas, G., Hafen, E. Nat. Cell Biol. (2003) [Pubmed]
  3. Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. van Slegtenhorst, M., Carr, E., Stoyanova, R., Kruger, W.D., Henske, E.P. J. Biol. Chem. (2004) [Pubmed]
  4. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Scott, R.C., Schuldiner, O., Neufeld, T.P. Dev. Cell (2004) [Pubmed]
  5. Drosophila Rheb GTPase is required for cell cycle progression and cell growth. Patel, P.H., Thapar, N., Guo, L., Martinez, M., Maris, J., Gau, C.L., Lengyel, J.A., Tamanoi, F. J. Cell. Sci. (2003) [Pubmed]
  6. Using Drosophila and Yeast Genetics to Investigate a Role for the Rheb GTPase in Cell Growth. Patel, P.H., Tamanoi, F. Meth. Enzymol. (2005) [Pubmed]
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