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Gene Review

Apbb1  -  amyloid beta (A4) precursor protein...

Mus musculus

Synonyms: Amyloid beta A4 precursor protein-binding family B member 1, Fe65, Protein Fe65, Rir
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Psychiatry related information on Apbb1


High impact information on Apbb1

  • The present study shows that 17beta-estradiol inhibits the transcriptional and apoptotic activities of the APPct complex by a process involving the interaction of estrogen receptor alpha (ERalpha) with Fe65 [2].
  • These results demonstrate that Fe65 plays an essential role in the response of the cells to DNA damage [3].
  • These mice do not show any obvious phenotype; however, when fibroblasts (mouse embryonic fibroblasts), isolated from Fe65 KO embryos, were exposed to low doses of DNA damaging agents, such as etoposide or H(2)O(2), an increased sensitivity to genotoxic stress, compared with wild type animals, clearly emerged [3].
  • Nuclear Fe65 is necessary to rescue the observed phenotype, and few minutes after the exposure of MEFs to DNA damaging agents, Fe65 undergoes phosphorylation in the nucleus [3].
  • Furthermore, APP-C59 binds to the DNA binding protein Fe65, although this does not increase the half-life of APP-C59 [4].

Biological context of Apbb1


Anatomical context of Apbb1


  1. Expression of the Fe65 adapter protein in adult and developing mouse brain. Kesavapany, S., Banner, S.J., Lau, K.F., Shaw, C.E., Miller, C.C., Cooper, J.D., McLoughlin, D.M. Neuroscience (2002) [Pubmed]
  2. Suppression of {beta}-Amyloid Precursor Protein Signaling into the Nucleus by Estrogens Mediated through Complex Formation between the Estrogen Receptor and Fe65. Bao, J., Cao, C., Zhang, X., Jiang, F., Nicosia, S.V., Bai, W. Mol. Cell. Biol. (2007) [Pubmed]
  3. Essential Roles for Fe65, Alzheimer Amyloid Precursor-binding Protein, in the Cellular Response to DNA Damage. Minopoli, G., Stante, M., Napolitano, F., Telese, F., Aloia, L., De Felice, M., Di Lauro, R., Pacelli, R., Brunetti, A., Zambrano, N., Russo, T. J. Biol. Chem. (2007) [Pubmed]
  4. The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. Cupers, P., Orlans, I., Craessaerts, K., Annaert, W., De Strooper, B. J. Neurochem. (2001) [Pubmed]
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