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Bsn  -  bassoon

Mus musculus

Synonyms: Kiaa0434, Protein bassoon, presynaptic cytomatrix protein
 
 
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High impact information on Bsn

  • Photoreceptor ribbons lacking Bassoon are not anchored to the presynaptic active zones [1].
  • Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex [2].
  • These represent 79 proteins, half of which are novel phosphoproteins, and include several highly phosphorylated proteins such as MAP1B (33 sites) and Bassoon (30 sites) [3].
  • Two days after manganese application, the cortex of Bassoon mutant mice appeared more laminated in ME-MRI, with an enhanced accumulation of manganese in deep, central, and superficial cortical cell layers [4].
  • Anatomical characterization revealed a significant increase in the total brain volume in Bassoon mutants as compared with wild-type mice, which is mainly caused by changes in cortex and hippocampus volume [4].
 

Biological context of Bsn

 

Associations of Bsn with chemical compounds

  • Manganese-enhanced MRI reveals structural and functional changes in the cortex of Bassoon mutant mice [4].
  • Whereas morphologically the cortical lamination is not affected by the absence of a functional Bassoon, an altered basal activation pattern was found in the cortex of the mutant mice both by metabolic labeling with [14C]-2-deoxyglucose and histochemical detection of the potassium analogue thallium uptake [4].
 

Other interactions of Bsn

  • A direct interaction between the ribbon-specific protein RIBEYE and Bassoon seems to link the two compartments and is responsible for the physical integrity of the photoreceptor ribbon complex [2].
  • This was shown by doubly labeling sections for GlyR alpha2 and bassoon (a presynaptic marker) or gephyrin (a postsynaptic marker) [6].
  • In conventional brain synapses, CAST forms a large molecular complex with other CAZ proteins, including RIM, Munc13-1, Bassoon, and Piccolo [7].
 

Analytical, diagnostic and therapeutic context of Bsn

  • Moreover, immunoelectron microscopy revealed that CAST, like Bassoon and RIM, localized at the base of synaptic ribbons, whereas ELKS localized around the ribbons [7].
  • Immunofluorescence analyses revealed that CAST and ELKS showed punctate signals in the outer and inner plexiform layers of the retina that were well-colocalized with those of Bassoon and RIM [7].

References

  1. The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina. Dick, O., tom Dieck, S., Altrock, W.D., Ammermüller, J., Weiler, R., Garner, C.C., Gundelfinger, E.D., Brandstätter, J.H. Neuron (2003) [Pubmed]
  2. Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex. tom Dieck, S., Altrock, W.D., Kessels, M.M., Qualmann, B., Regus, H., Brauner, D., Fejtová, A., Bracko, O., Gundelfinger, E.D., Brandstätter, J.H. J. Cell Biol. (2005) [Pubmed]
  3. Proteomic analysis of in vivo phosphorylated synaptic proteins. Collins, M.O., Yu, L., Coba, M.P., Husi, H., Campuzano, I., Blackstock, W.P., Choudhary, J.S., Grant, S.G. J. Biol. Chem. (2005) [Pubmed]
  4. Manganese-enhanced MRI reveals structural and functional changes in the cortex of Bassoon mutant mice. Angenstein, F., Niessen, H.G., Goldschmidt, J., Lison, H., Altrock, W.D., Gundelfinger, E.D., Scheich, H. Cereb. Cortex (2007) [Pubmed]
  5. The presynaptic cytomatrix protein Bassoon: sequence and chromosomal localization of the human BSN gene. Winter, C., tom Dieck, S., Boeckers, T.M., Bockmann, J., Kämpf, U., Sanmartí-Vila, L., Langnaese, K., Altrock, W., Stumm, M., Soyke, A., Wieacker, P., Garner, C.C., Gundelfinger, E.D. Genomics (1999) [Pubmed]
  6. Diversity of glycine receptors in the mouse retina: localization of the alpha2 subunit. Haverkamp, S., Müller, U., Zeilhofer, H.U., Harvey, R.J., Wässle, H. J. Comp. Neurol. (2004) [Pubmed]
  7. Active zone protein CAST is a component of conventional and ribbon synapses in mouse retina. Deguchi-Tawarada, M., Inoue, E., Takao-Rikitsu, E., Inoue, M., Kitajima, I., Ohtsuka, T., Takai, Y. J. Comp. Neurol. (2006) [Pubmed]
 
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