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Bsn  -  bassoon (presynaptic cytomatrix protein)

Rattus norvegicus

Synonyms: Protein bassoon
 
 
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High impact information on Bsn

  • Quantitative analysis reveals that the Bassoon, Piccolo, and RIM content of individual PTVs is, on average, half of that of individual presynaptic boutons and shows that the synaptic content of these molecules can be quantitatively accounted for by incorporation of integer numbers (typically two to three) of PTVs into presynaptic membranes [1].
  • By combining immunocytochemistry and transfection of cultured hippocampal neurons, we show that the central portion of Bassoon is crucially involved in synaptic targeting and CAZ association [2].
  • Our data provide the first experimental evidence for the existence of distinct functional regions in Bassoon and suggest that a centrally located CAZ targeting function may be complemented by an N-terminal capacity for targeting to membrane-bounded synaptic organelles [2].
  • In this study, we have investigated a possible role for Bassoon in synaptogenesis and in defining synaptic vesicle recycling sites [3].
  • As synaptogenesis begins, Bassoon clusters appear along dendritic profiles simultaneously with synaptotagmin I, sites of synaptic vesicle recycling, and the acquisition of functional excitatory and inhibitory synapses [3].
 

Anatomical context of Bsn

  • As in the brain, bassoon was found at conventional inhibitory GABAergic synapses, made by amacrine cells, but it was absent from the bipolar cell ribbon synapses [4].
  • Using pre- and post-embedding immunostaining and electron microscopy, bassoon was localized in the outer plexiform layer at ribbon synapses formed by rods and cones but was absent from basal synaptic contacts formed by cones [4].
  • Endogenous and exogenously expressed ELKS, RIM2 and Bassoon were colocalized in punctate signals in PC12 cells [5].
  • We studied the distribution of Bassoon transcripts and protein in rat brain and assessed which types of presynaptic terminals contain the protein [6].
  • Bassoon-containing symmetric synapses are observed, e.g., between basket and granule cells in the hippocampus, between Golgi cells and granule cells, and between basket cells and Purkinje cells in the cerebellum [6].
 

Associations of Bsn with chemical compounds

 

Other interactions of Bsn

 

Analytical, diagnostic and therapeutic context of Bsn

References

  1. Unitary assembly of presynaptic active zones from Piccolo-Bassoon transport vesicles. Shapira, M., Zhai, R.G., Dresbach, T., Bresler, T., Torres, V.I., Gundelfinger, E.D., Ziv, N.E., Garner, C.C. Neuron (2003) [Pubmed]
  2. Functional regions of the presynaptic cytomatrix protein bassoon: significance for synaptic targeting and cytomatrix anchoring. Dresbach, T., Hempelmann, A., Spilker, C., tom Dieck, S., Altrock, W.D., Zuschratter, W., Garner, C.C., Gundelfinger, E.D. Mol. Cell. Neurosci. (2003) [Pubmed]
  3. Temporal appearance of the presynaptic cytomatrix protein bassoon during synaptogenesis. Zhai, R., Olias, G., Chung, W.J., Lester, R.A., tom Dieck, S., Langnaese, K., Kreutz, M.R., Kindler, S., Gundelfinger, E.D., Garner, C.C. Mol. Cell. Neurosci. (2000) [Pubmed]
  4. Differential expression of the presynaptic cytomatrix protein bassoon among ribbon synapses in the mammalian retina. Brandstätter, J.H., Fletcher, E.L., Garner, C.C., Gundelfinger, E.D., Wässle, H. Eur. J. Neurosci. (1999) [Pubmed]
  5. ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+-dependent exocytosis from PC12 cells. Inoue, E., Deguchi-Tawarada, M., Takao-Rikitsu, E., Inoue, M., Kitajima, I., Ohtsuka, T., Takai, Y. Genes Cells (2006) [Pubmed]
  6. Presynaptic cytomatrix protein bassoon is localized at both excitatory and inhibitory synapses of rat brain. Richter, K., Langnaese, K., Kreutz, M.R., Olias, G., Zhai, R., Scheich, H., Garner, C.C., Gundelfinger, E.D. J. Comp. Neurol. (1999) [Pubmed]
  7. Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling. Hagiwara, A., Fukazawa, Y., Deguchi-Tawarada, M., Ohtsuka, T., Shigemoto, R. J. Comp. Neurol. (2005) [Pubmed]
  8. Regressive and reactive changes in the connectivity patterns of rod and cone pathways of P23H transgenic rat retina. Cuenca, N., Pinilla, I., Sauvé, Y., Lu, B., Wang, S., Lund, R.D. Neuroscience (2004) [Pubmed]
  9. Localization of the presynaptic cytomatrix protein Piccolo at ribbon and conventional synapses in the rat retina: comparison with Bassoon. Dick, O., Hack, I., Altrock, W.D., Garner, C.C., Gundelfinger, E.D., Brandstätter, J.H. J. Comp. Neurol. (2001) [Pubmed]
  10. Early changes in synaptic connectivity following progressive photoreceptor degeneration in RCS rats. Cuenca, N., Pinilla, I., Sauvé, Y., Lund, R. Eur. J. Neurosci. (2005) [Pubmed]
 
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