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Gene Review

BSN  -  bassoon presynaptic cytomatrix protein

Homo sapiens

Synonyms: KIAA0434, Protein bassoon, ZNF231, Zinc finger protein 231
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Disease relevance of BSN


Psychiatry related information on BSN

  • By utilizing teaching strategies of creativity in a teaching protocol of nursing concepts, it is expected that two-year RN-BSN students can acquire characteristics of creativity for problem-solving skills in clinical settings [6].
  • Lesbian phobia among BSN educators: a survey [7].
  • The purpose of this study was to evaluate two classes of BSN student's perceptions of viewing films as an alternative to some clinical time in a psychiatric mental-health nursing course [8].
  • Thinking about returning to school? Decision-making for RN-BSN education [9]!
  • Risk-taking propensity of nurses: ADN and BSN [10].

High impact information on BSN

  • SAD-B is associated with synaptic vesicles and, like the active zone proteins CAST and Bassoon, is tightly associated with the presynaptic cytomatrix in nerve terminals [11].
  • BRP shows homology to human AZ protein ELKS/CAST/ERC, which binds RIM1 in a complex with Bassoon and Munc13-1 [12].
  • Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses [3].
  • The protein Bassoon is found in the cytoskeletal matrix at the active zone of conventional synapses and in presynaptic ribbons of photoreceptor synapses [13].
  • Piccolo, a presynaptic zinc finger protein structurally related to bassoon [14].

Biological context of BSN


Anatomical context of BSN

  • Immunogold labeling of synaptosomes revealed that Bassoon is associated with material interspersed between clear synaptic vesicles, and biochemical studies suggest a tight association with cytoskeletal structures [15].
  • Here we show that Bassoon, a novel protein of >400,000 Mr, is a new component of the presynaptic cytoskeleton [15].
  • At the ultrastructural level, Bassoon is detected in axon terminals of hippocampal neurons where it is highly concentrated in the vicinity of the active zone [15].
  • In contrast, varicosities of the vas deferens contain a subset of active zone proteins including Bassoon and ELKS2, with the other four components being absent [16].
  • Endogenous and exogenously expressed ELKS, RIM2 and Bassoon were colocalized in punctate signals in PC12 cells [19].

Associations of BSN with chemical compounds


Other interactions of BSN

  • Recently, major protein constituents of active zones have been identified, including the proteins Piccolo, Bassoon, RIM, Munc13, ERCs/ELKs/CASTs and liprins [16].
  • Credit requirements for core and major courses were found to vary dramatically, as do credits required to earn the BSN-MSN credential; the average number of credits for program completion was 127 [23].
  • These results demonstrate that Bassoon and Piccolo are stable components of the active zone while RIM 1, synapsin I and synuclein undergo dynamic redistribution with synaptic activity [24].
  • Munc13, Rim, Bassoon and Piccolo/Aczonin are recently identified presynaptic cytomatrix proteins [25].
  • After stimulation, Bassoon and Piccolo remained relatively unchanged, but RIM 1 redistributed with a significant decrease in zone I, and increases in zones II and III [24].

Analytical, diagnostic and therapeutic context of BSN

  • Among BSN students, the most prevalent stresses were coping with demands associated with patient care and the clinical teacher [26].
  • A cross-sectional survey (n = 170) of graduating BSN students (n = 73) and MS and PhD students (n = 47) and faculty (n = 50) was conducted in a university-based nursing program [27].
  • RESULTS: The majority of respondents worked full time (83%) and were BSN (Bachelor of Science in Nursing) prepared (62%), with an average of 9 years' nursing experience and 7 years' experience in intensive care [28].
  • Lynne McCain, BSN, RN, of Emory Clinic's Section of Plastic and Reconstructive Surgery in Atlanta, provides common questions asked by patients with breast implants followed by appropriate responses that could be given in counseling [29].
  • The purpose of this study was to describe the knowledge and attitudes of nursing faculty and students (BSN and MS) regarding complementary/alternative therapies (C/AT) and their integration into nursing practice [27].


  1. The presynaptic cytomatrix protein Bassoon: sequence and chromosomal localization of the human BSN gene. Winter, C., tom Dieck, S., Boeckers, T.M., Bockmann, J., Kämpf, U., Sanmartí-Vila, L., Langnaese, K., Altrock, W., Stumm, M., Soyke, A., Wieacker, P., Garner, C.C., Gundelfinger, E.D. Genomics (1999) [Pubmed]
  2. Cloning and mapping of ZNF231, a novel brain-specific gene encoding neuronal double zinc finger protein whose expression is enhanced in a neurodegenerative disorder, multiple system atrophy (MSA). Hashida, H., Goto, J., Zhao, N., Takahashi, N., Hirai, M., Kanazawa, I., Sakaki, Y. Genomics (1998) [Pubmed]
  3. Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. Altrock, W.D., tom Dieck, S., Sokolov, M., Meyer, A.C., Sigler, A., Brakebusch, C., Fässler, R., Richter, K., Boeckers, T.M., Potschka, H., Brandt, C., Löscher, W., Grimberg, D., Dresbach, T., Hempelmann, A., Hassan, H., Balschun, D., Frey, J.U., Brandstätter, J.H., Garner, C.C., Rosenmund, C., Gundelfinger, E.D. Neuron (2003) [Pubmed]
  4. A Tri-Level HIV-Prevention Educational Intervention. Brown, E.J., Smith, F.B. International journal of nursing education scholarship [electronic resource]. (2005) [Pubmed]
  5. Faculty and internships. A match made in heaven? Fanelli, S. Journal for nurses in staff development : JNSD : official journal of the National Nursing Staff Development Organization. (1998) [Pubmed]
  6. The effectiveness of teaching strategies for creativity in a nursing concepts teaching protocol on the creative thinking of two-year RN-BSN students. Ku, Y.L., Kao Lo, C.H., Wang, J.J., Lee Hsieh, J., Chen, K.M. The journal of nursing research : JNR. (2002) [Pubmed]
  7. Lesbian phobia among BSN educators: a survey. Randall, C.E. The Journal of nursing education. (1989) [Pubmed]
  8. Hollywood in the classroom: using feature films to teach. Masters, J.C. Nurse educator. (2005) [Pubmed]
  9. Thinking about returning to school? Decision-making for RN-BSN education! Blais, K., Sandiford, J. The Florida nurse. (1994) [Pubmed]
  10. Risk-taking propensity of nurses: ADN and BSN. Masters, M.L., Masters, R.J. The Journal of nursing education. (1989) [Pubmed]
  11. SAD: A Presynaptic Kinase Associated with Synaptic Vesicles and the Active Zone Cytomatrix that Regulates Neurotransmitter Release. Inoue, E., Mochida, S., Takagi, H., Higa, S., Deguchi-Tawarada, M., Takao-Rikitsu, E., Inoue, M., Yao, I., Takeuchi, K., Kitajima, I., Setou, M., Ohtsuka, T., Takai, Y. Neuron (2006) [Pubmed]
  12. Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. Wagh, D.A., Rasse, T.M., Asan, E., Hofbauer, A., Schwenkert, I., Dürrbeck, H., Buchner, S., Dabauvalle, M.C., Schmidt, M., Qin, G., Wichmann, C., Kittel, R., Sigrist, S.J., Buchner, E. Neuron (2006) [Pubmed]
  13. Bassoon's part in two presynaptic orchestras. Wilson, M. Neuron (2003) [Pubmed]
  14. Piccolo, a presynaptic zinc finger protein structurally related to bassoon. Fenster, S.D., Chung, W.J., Zhai, R., Cases-Langhoff, C., Voss, B., Garner, A.M., Kaempf, U., Kindler, S., Gundelfinger, E.D., Garner, C.C. Neuron (2000) [Pubmed]
  15. Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals. tom Dieck, S., Sanmartí-Vila, L., Langnaese, K., Richter, K., Kindler, S., Soyke, A., Wex, H., Smalla, K.H., Kämpf, U., Fränzer, J.T., Stumm, M., Garner, C.C., Gundelfinger, E.D. J. Cell Biol. (1998) [Pubmed]
  16. Differential expression of active zone proteins in neuromuscular junctions suggests functional diversification. Juranek, J., Mukherjee, K., Rickmann, M., Martens, H., Calka, J., S??dhof, T.C., Jahn, R. Eur. J. Neurosci. (2006) [Pubmed]
  17. New horizons: fostering BSN students' interest in nursing research. Walsh, S.M. Nurse educator. (2000) [Pubmed]
  18. Addressing the public health nursing shortage: university-health department collaborative experience for BSN students. Alexander, J.W. South Carolina nurse (Columbia, S.C. : 1994) (2005) [Pubmed]
  19. ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+-dependent exocytosis from PC12 cells. Inoue, E., Deguchi-Tawarada, M., Takao-Rikitsu, E., Inoue, M., Kitajima, I., Ohtsuka, T., Takai, Y. Genes Cells (2006) [Pubmed]
  20. Dopamine elicits feeding motor program in Limax maximus. Wieland, S.J., Gelperin, A. J. Neurosci. (1983) [Pubmed]
  21. Sharing with the land of the dancing lights. Mahara, M.S., Bowen, D., Brennan, J., Crawford, L., Gomez, L., Parsons, L. The Canadian nurse. (2005) [Pubmed]
  22. Profile of Sherri Kensall, RN, BSN, Renal Care Coordinator, Fraser Health Authority, British Columbia. Interview by Kate Hughes. Kensall, S. CANNT journal = Journal ACITN. (2004) [Pubmed]
  23. RN-MSN admission practices and curricula in the mid-Atlantic region. Speziale, H.J. Nursing education perspectives. (2002) [Pubmed]
  24. Activity-related redistribution of presynaptic proteins at the active zone. Tao-Cheng, J.H. Neuroscience (2006) [Pubmed]
  25. Molecular determinants of presynaptic active zones. Garner, C.C., Kindler, S., Gundelfinger, E.D. Curr. Opin. Neurobiol. (2000) [Pubmed]
  26. Differences in clinical experiences of ADN and BSN students. Oermann, M.H. The Journal of nursing education. (1998) [Pubmed]
  27. Complementary therapies and healing practices: faculty/student beliefs and attitudes and the implications for nursing education. Halcón, L.L., Chlan, L.L., Kreitzer, M.J., Leonard, B.J. Journal of professional nursing : official journal of the American Association of Colleges of Nursing. (2003) [Pubmed]
  28. Nurses' knowledge and attitudes about antibiotic therapy in critical care. Munro, C.L., Grap, M.J. Intensive & critical care nursing : the official journal of the British Association of Critical Care Nurses. (2001) [Pubmed]
  29. Counseling the woman with silicone breast implants. McCain, L. Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses. (1992) [Pubmed]
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