Disease relevance of BSN

• Phage clones spanning most of the open reading frame and the 3' untranslated region were isolated from a human genomic library and used for chromosomal localization of BSN to chromosome 3p21 by FISH [1].
• Elevation of ZNF231 expression may be involved in the pathogenesis of multiple system atrophy [2].
• Phenotypically, the loss of Bassoon causes spontaneous epileptic seizures [3].
• The initiative described provided HIV education at three levels: to students in an R.N. to BSN program, lay health advisors (LHA's), and participants in a high-risk community [4].
• Program goals included facilitating growth and development of 21 newly graduated BSN nurses to prepare them to care for a critically ill adult [5].

Psychiatry related information on BSN

• By utilizing teaching strategies of creativity in a teaching protocol of nursing concepts, it is expected that two-year RN-BSN students can acquire characteristics of creativity for problem-solving skills in clinical settings [6].
• Lesbian phobia among BSN educators: a survey [7].
• The purpose of this study was to evaluate two classes of BSN student's perceptions of viewing films as an alternative to some clinical time in a psychiatric mental-health nursing course [8].
• Thinking about returning to school? Decision-making for RN-BSN education [9]!
• Risk-taking propensity of nurses: ADN and BSN [10].

High impact information on BSN

• SAD-B is associated with synaptic vesicles and, like the active zone proteins CAST and Bassoon, is tightly associated with the presynaptic cytomatrix in nerve terminals [11].
• BRP shows homology to human AZ protein ELKS/CAST/ERC, which binds RIM1 in a complex with Bassoon and Munc13-1 [12].
• Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses [3].
• The protein Bassoon is found in the cytoskeletal matrix at the active zone of conventional synapses and in presynaptic ribbons of photoreceptor synapses [13].
• Piccolo, a presynaptic zinc finger protein structurally related to bassoon [14].

Biological context of BSN

• The murine bassoon gene maps to chromosome 9F [15].
• A novel brain-specific gene, neuronal double zinc finger protein (ZNF231), was cloned and mapped [2].
• We conclude that Bassoon and ELKS2 perform independent and specialized functions in synaptic transmission of autonomic synapses [16].
• New horizons: fostering BSN students' interest in nursing research [17].
• Addressing the public health nursing shortage: university-health department collaborative experience for BSN students [18].

Anatomical context of BSN

• Immunogold labeling of synaptosomes revealed that Bassoon is associated with material interspersed between clear synaptic vesicles, and biochemical studies suggest a tight association with cytoskeletal structures [15].
• Here we show that Bassoon, a novel protein of >400,000 Mr, is a new component of the presynaptic cytoskeleton [15].
• At the ultrastructural level, Bassoon is detected in axon terminals of hippocampal neurons where it is highly concentrated in the vicinity of the active zone [15].
• In contrast, varicosities of the vas deferens contain a subset of active zone proteins including Bassoon and ELKS2, with the other four components being absent [16].
• Endogenous and exogenously expressed ELKS, RIM2 and Bassoon were colocalized in punctate signals in PC12 cells [19].

Associations of BSN with chemical compounds

• Since it is known for some proteins that abnormal amplification of such polyglutamine regions can cause late-onset neurodegeneration, we cloned and localized the human BASSOON gene (BSN) [1].
• The effects of exogenous serotonin differed from dopamine's effects; serotonin excited BSN and several buccal motor neurons, could not elicit synchronized motor program cycling, and was not efficiently blocked by ergonovine [20].
• Exogenous dopamine applied to the cerebral and buccal ganglia in vitro between 10(-7) M and 3 X 10(-6) M excited an autoactive salivary duct motor neuron (FB) and inhibited an autoactive secretomotor neuron (BSN) [20].
• In 2001, Aurora College in Yellowknife, Northwest Territories, entered into contract with the Collaborative Nursing Program (CNP) in British Columbia to develop a four-year BSN program [21].
• Profile of Sherri Kensall, RN, BSN, Renal Care Coordinator, Fraser Health Authority, British Columbia. Interview by Kate Hughes [22].

Other interactions of BSN

• Recently, major protein constituents of active zones have been identified, including the proteins Piccolo, Bassoon, RIM, Munc13, ERCs/ELKs/CASTs and liprins [16].
• Credit requirements for core and major courses were found to vary dramatically, as do credits required to earn the BSN-MSN credential; the average number of credits for program completion was 127 [23].
• These results demonstrate that Bassoon and Piccolo are stable components of the active zone while RIM 1, synapsin I and synuclein undergo dynamic redistribution with synaptic activity [24].
• Munc13, Rim, Bassoon and Piccolo/Aczonin are recently identified presynaptic cytomatrix proteins [25].
• After stimulation, Bassoon and Piccolo remained relatively unchanged, but RIM 1 redistributed with a significant decrease in zone I, and increases in zones II and III [24].

Analytical, diagnostic and therapeutic context of BSN

• Among BSN students, the most prevalent stresses were coping with demands associated with patient care and the clinical teacher [26].
• A cross-sectional survey (n = 170) of graduating BSN students (n = 73) and MS and PhD students (n = 47) and faculty (n = 50) was conducted in a university-based nursing program [27].
• RESULTS: The majority of respondents worked full time (83%) and were BSN (Bachelor of Science in Nursing) prepared (62%), with an average of 9 years' nursing experience and 7 years' experience in intensive care [28].
• Lynne McCain, BSN, RN, of Emory Clinic's Section of Plastic and Reconstructive Surgery in Atlanta, provides common questions asked by patients with breast implants followed by appropriate responses that could be given in counseling [29].
• The purpose of this study was to describe the knowledge and attitudes of nursing faculty and students (BSN and MS) regarding complementary/alternative therapies (C/AT) and their integration into nursing practice [27].

References