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Gene Review:

orf75 - transcriptional regulator

Proteus vulgaris

Tölg, M. et al., Hay, N.A. et al., Trépanier, S. et al., Morrow, B.J. et al., Poore, C.A. et al.

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Disease relevance of orf75

Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator [1].
This putative transcriptional regulator was absent from the genomes of the human-adapted serovars S. typhi and Salmonella paratyphi A [2].
A nonswarming mutant of Proteus mirabilis lacks the Lrp global transcriptional regulator [3].
The mobilizable plasmid pMD101 (ampR, ampC) was constructed by inserting cloned ampC, the structural gene for the chromosomal AmpC beta-lactamase of Citrobacter freundii, and the closely linked ampR encoding the transcriptional regulator essential for enzyme induction, into the broad host-range plasmid pKT231 [4].

High impact information on orf75

Identification of the domains of UreR, an AraC-like transcriptional regulator of the urease gene cluster in Proteus mirabilis [5].
The transposon had inserted in the gene encoding the global transcriptional regulator Lrp (leucine-responsive regulatory protein), expression of which was upregulated in differentiating swarm cells [3].

References

Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Trépanier, S., Prince, A., Huletsky, A. Antimicrob. Agents Chemother. (1997) [Pubmed]
Genomic subtractive hybridization and selective capture of transcribed sequences identify a novel Salmonella typhimurium fimbrial operon and putative transcriptional regulator that are absent from the Salmonella typhi genome. Morrow, B.J., Graham, J.E., Curtiss, R. Infect. Immun. (1999) [Pubmed]
A nonswarming mutant of Proteus mirabilis lacks the Lrp global transcriptional regulator. Hay, N.A., Tipper, D.J., Gygi, D., Hughes, C. J. Bacteriol. (1997) [Pubmed]
Dependence of induction of enterobacterial AmpC beta-lactamase on cell-wall peptidoglycan, as demonstrated in Proteus mirabilis and its wall-less protoplast L-form. Tölg, M., Schmidt, H., Schierl, R., Datz, M., Martin, H.H. J. Gen. Microbiol. (1993) [Pubmed]
Identification of the domains of UreR, an AraC-like transcriptional regulator of the urease gene cluster in Proteus mirabilis. Poore, C.A., Coker, C., Dattelbaum, J.D., Mobley, H.L. J. Bacteriol. (2001) [Pubmed]

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