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Ccng2  -  cyclin G2

Mus musculus

Synonyms: Cyclin-G2
 
 
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High impact information on Ccng2

 

Biological context of Ccng2

  • Each of the promoter sequences has consensus binding sites for the deltaEF1 transcription factor, previously shown to either repress or activate different promoters. deltaEF1 bound to the Ccng2 and Rbl2 promoters in vitro and in vivo and increased reporter activity as well as endogenous mRNA levels for these genes [2].
  • Here we studied the mechanisms that regulate cyclin G2 mRNA expression during the cell cycle [1].
  • Cyclin G2 is highly expressed in the immune system where immunologic tolerance subjects self-reactive lymphocytes to negative selection and clonal deletion via apoptosis [3].
 

Anatomical context of Ccng2

  • This prompted us to examine the roles of two negative growth-regulatory genes, cyclin G1 and cyclin G2, in the periimplantation mouse uterus [4].
  • Here we investigated the effect of growth inhibitory signals on cyclin G2 mRNA abundance in different maturation stage-specific murine B cell lines [3].
 

Associations of Ccng2 with chemical compounds

  • Pharmacological and genetic studies provide evidence that the expression of cyclin G1, not cyclin G2, is regulated by progesterone via its nuclear receptor [4].
  • Because the phosphoinositide 3-kinase pathway inhibits the FoxO family of forkhead transcription factors, we examined the involvement of these factors in the regulation of cyclin G2 expression [1].
  • Upon treatment of wild-type and p53 null B cell lines with the negative growth factor, transforming growth factor beta1, or the growth inhibitory corticosteroid dexamethasone, cyclin G2 mRNA levels were increased in a time-dependent manner 5-14-fold over control cell levels [3].
 

Other interactions of Ccng2

References

  1. Control of cyclin G2 mRNA expression by forkhead transcription factors: novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead. Martínez-Gac, L., Marqués, M., García, Z., Campanero, M.R., Carrera, A.C. Mol. Cell. Biol. (2004) [Pubmed]
  2. FOXO transcription factors cooperate with delta EF1 to activate growth suppressive genes in B lymphocytes. Chen, J., Yusuf, I., Andersen, H.M., Fruman, D.A. J. Immunol. (2006) [Pubmed]
  3. Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest. Horne, M.C., Donaldson, K.L., Goolsby, G.L., Tran, D., Mulheisen, M., Hell, J.W., Wahl, A.F. J. Biol. Chem. (1997) [Pubmed]
  4. Cyclin G1 and cyclin G2 are expressed in the periimplantation mouse uterus in a cell-specific and progesterone-dependent manner: evidence for aberrant regulation with Hoxa-10 deficiency. Yue, L., Daikoku, T., Hou, X., Li, M., Wang, H., Nojima, H., Dey, S.K., Das, S.K. Endocrinology (2005) [Pubmed]
 
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