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Gene Review

Cct6a  -  chaperonin containing Tcp1, subunit 6a (zeta)

Mus musculus

Synonyms: CCT-zeta, CCT-zeta-1, Cct6, Cctz, Cctz-1, ...
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High impact information on Cct6a

  • The type II chaperonin CCT (chaperonin containing Tcp-1) of eukaryotic cytosol is a heteromeric 16-mer particle composed of eight different subunits [1].
  • Proteomic analyses of mouse brains by two-dimensional differential gel electrophoresis showed that several proteins, including growth hormone, 1-Cys peroxiredoxin, CCT-zeta, glucose-6-phosphate isomerase, GRP170 precursor, and alpha-SNAP, were differentially expressed [2].
  • As mouse NK cells do not express CD56, comparable mouse NK cell subsets have proven difficult to identify [3].
  • The chaperonin containing TCP-1 (CCT) of eukaryotic cytosol is composed of eight different subunit species that are proposed to have independent functions in folding its in vivo substrates, the actins and tubulins [4].
  • Folding of alpha- and beta-tubulin is mediated by the cytoplasmic chaperonin containing TCP-1 (CCT), highly expressed in testis [5].

Biological context of Cct6a


Anatomical context of Cct6a


  1. 3D reconstruction of the ATP-bound form of CCT reveals the asymmetric folding conformation of a type II chaperonin. Llorca, O., Smyth, M.G., Carrascosa, J.L., Willison, K.R., Radermacher, M., Steinbacher, S., Valpuesta, J.M. Nat. Struct. Biol. (1999) [Pubmed]
  2. Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein. Steinacker, P., Schwarz, P., Reim, K., Brechlin, P., Jahn, O., Kratzin, H., Aitken, A., Wiltfang, J., Aguzzi, A., Bahn, E., Baxter, H.C., Brose, N., Otto, M. Mol. Cell. Biol. (2005) [Pubmed]
  3. Functional subsets of mouse natural killer cells. Hayakawa, Y., Huntington, N.D., Nutt, S.L., Smyth, M.J. Immunol. Rev. (2006) [Pubmed]
  4. Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin. Hynes, G.M., Willison, K.R. J. Biol. Chem. (2000) [Pubmed]
  5. The cytosolic chaperonin CCT associates to cytoplasmic microtubular structures during mammalian spermiogenesis and to heterochromatin in germline and somatic cells. Souès, S., Kann, M.L., Fouquet, J.P., Melki, R. Exp. Cell Res. (2003) [Pubmed]
  6. Structures and co-regulated expression of the genes encoding mouse cytosolic chaperonin CCT subunits. Kubota, H., Yokota, S., Yanagi, H., Yura, T. Eur. J. Biochem. (1999) [Pubmed]
  7. Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma. Walkley, N.A., Demaine, A.G., Malik, A.N. Biochem. J. (1996) [Pubmed]
  8. Chromosomal assignment and imprinting tests for the mouse delta subunit of the cytosolic chaperonin containing TCP-1 (Cct4) gene to proximal chromosome 11. Nabetani, A., Hatada, I., Morisaki, H., Mukai, T. Genomics (1996) [Pubmed]
  9. Mapping of G2/M-phase prevalences of chaperon-encoding transcripts by means of a sensitive differential hybridization approach. Dittmar, G., Schmidt, G., Kopun, M., Werner, D. Cell Biol. Int. (1997) [Pubmed]
  10. Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. Kubota, H., Hynes, G.M., Kerr, S.M., Willison, K.R. FEBS Lett. (1997) [Pubmed]
  11. The chaperonin containing t-complex polypeptide 1 (TCP-1). Multisubunit machinery assisting in protein folding and assembly in the eukaryotic cytosol. Kubota, H., Hynes, G., Willison, K. Eur. J. Biochem. (1995) [Pubmed]
  12. Analysis of chaperonin-containing TCP-1 subunits in the human keratinocyte two-dimensional protein database: further characterisation of antibodies to individual subunits. Hynes, G., Celis, J.E., Lewis, V.A., Carne, A., U, S., Lauridsen, J.B., Willison, K.R. Electrophoresis (1996) [Pubmed]
  13. The chaperonin containing TCP-1 (CCT) displays a single-ring mediated disassembly and reassembly cycle. Liou, A.K., McCormack, E.A., Willison, K.R. Biol. Chem. (1998) [Pubmed]
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