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Gene Review

CCT6A  -  chaperonin containing TCP1, subunit 6A...

Homo sapiens

Synonyms: Acute morphine dependence-related protein 2, CCT-zeta, CCT-zeta-1, CCT6, CCTZ, ...
 
 
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Disease relevance of CCT6A

  • CD56-positive cutaneous lymphoma: a poorly recognized entity in the spectrum of primary cutaneous disease [1].
  • Interestingly, the heightened CD56+CD3-, CD56+CD3+, CD56+TIA-1+ and CD56+CD11a+ cell rates are associated with mild dengue clinical manifestations and might indicate a good prognosis of the disease [2].
  • Immunohistochemical expression of natural killer T (NKT) cell-associated markers (Valpha24 and CD56) and perforin in relation to CD44-highly positive (CD44(high)) cells was studied in hyperplastic thymuses from patients with myasthenia gravis (MG) whose symptoms dramatically improved after thymectomy and compared with non-MG control thymuses [3].
  • On diagnosis, patients who would require a radical treatment for thyrotoxicosis control showed a significant decrease of cytotoxic CD56+ T (CD3+) and NK (CD3-) cells compared with those who would maintain the euthyroid state after methimazole [4].
  • MATERIALS AND METHODS: Frozen sections from ameloblastoma specimens (n = 7) were stained with monoclonal antibody-recognizing CD56 and CD147 molecules using indirect immunoperoxidase and indirect immunofluorescent techniques [5].
 

High impact information on CCT6A

  • As mouse NK cells do not express CD56, comparable mouse NK cell subsets have proven difficult to identify [6].
  • The amino acid sequence similarities and the derived evolutionary relationships established that the human and yeast Tcp20 proteins represent members of a new family of subunits of TRiC chaperonins [7].
  • Gel filtration, followed by Western analysis of purified bovine testis TRiC with a Tcp20-specific antibody, indicated that Tcp20 is a subunit of the hetero-oligomeric TRiC [7].
  • Gene disruption experiments showed that TCP20, like TCP1, is an essential gene in yeast, consistent with the view that TRiC is required for folding of key proteins [7].
  • We have established greater than 57% identity between a protein encoded by the TCP20 gene from a human cDNA library and the newly identified protein encoded by the TCP20 gene located on the right arm of chromosome IV of the yeast Saccharomyces cerevisiae [7].
 

Biological context of CCT6A

  • The rabbit CCT6 was 93% identical to the human gene; the deduced amino acid sequence was 97% identical [8].
  • The CD27(hi) and CD27(lo) mouse NK cell subsets show some intriguing similarities to but also some distinct differences from the human CD56 NK cell subsets in terms of their function and phenotype [6].
  • PURPOSE: The objective of the present study was to determine whether neural cell adhesion molecules (NCAM; CD56) and neurothelin (CD147) are expressed by adontogenic cells in the ameloblastoma [5].
 

Anatomical context of CCT6A

  • We used the cDNA of the human CCT6 subunit to obtain a full-length cDNA from a rabbit kidney cortex library [8].
  • Human natural killer (NK) cells can be divided into two phenotypically distinct functional subsets based on their cell surface expression of CD56 (CD56(bright) and CD56(dim)) [6].
  • Immunogenotypic analyses suggested the natural killer cell origin of these neoplasias: all cases exhibited a CD56+ CD3- CD5- T-cell receptor (TCR) silent phenotype, and Southern blot analysis showed a germline configuration of the TCR beta-chain gene [1].
  • CD56-positive (CD56+) lymphomas, characterized by the expression of the neural cell adhesion molecule on pathological lymphocytes, share a frequent extranodal involvement and a generally aggressive course [1].
  • In contrast, in hyperplastic MG thymus, Valpha24(+) and CD56(+) cells were more frequent in connective tissue, appeared to have penetrated the thymic parenchyma, and most coexpressed CD44(high) [3].
 

Other interactions of CCT6A

  • These include genes encoding a GAP-associated p62 protein, histone H2A.Z, a subunit of the small nuclear ribonucleoprotein complex, and the chaperonin Tcp20, and a cellular immediate-early-response gene [9].
 

Analytical, diagnostic and therapeutic context of CCT6A

References

  1. CD56-positive cutaneous lymphoma: a poorly recognized entity in the spectrum of primary cutaneous disease. Savoia, P., Fierro, M.T., Novelli, M., Quaglino, P., Verrone, A., Geuna, M., Bernengo, M.G. Br. J. Dermatol. (1997) [Pubmed]
  2. NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease. Azeredo, E.L., De Oliveira-Pinto, L.M., Zagne, S.M., Cerqueira, D.I., Nogueira, R.M., Kubelka, C.F. Clin. Exp. Immunol. (2006) [Pubmed]
  3. NKT-associated markers and perforin in hyperplastic thymuses from patients with Myasthenia gravis. Nagane, Y., Utsugisawa, K., Obara, D., Tohgi, H. Muscle Nerve (2001) [Pubmed]
  4. Serial analysis of the effects of methimazole or radical therapy on circulating CD16/56 subpopulations in Graves' disease. Rojano, J., Sasián, S., Gavilán, I., Aguilar, M., Escobar, L., Girón, J.A. Eur. J. Endocrinol. (1998) [Pubmed]
  5. Neural cell adhesion molecule and neurothelin expression in human ameloblastoma. Er, N., Dağdeviren, A., Taşman, F., Zeybek, D. J. Oral Maxillofac. Surg. (2001) [Pubmed]
  6. Functional subsets of mouse natural killer cells. Hayakawa, Y., Huntington, N.D., Nutt, S.L., Smyth, M.J. Immunol. Rev. (2006) [Pubmed]
  7. Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast. Li, W.Z., Lin, P., Frydman, J., Boal, T.R., Cardillo, T.S., Richard, L.M., Toth, D., Lichtman, M.A., Hartl, F.U., Sherman, F. J. Biol. Chem. (1994) [Pubmed]
  8. Cloning of rabbit Cct6 and the distribution of the Cct complex in mammalian tissues. Schwartz, G.J., Kittelberger, A.M., Segel, G.B. Exp. Nephrol. (2000) [Pubmed]
  9. Heme initiates changes in the expression of a wide array of genes during the early erythroid differentiation stage. Zhu, Y., Hon, T., Zhang, L. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  10. OK-432 therapy for lymphangioma in children: why and how does it work? Ogita, S., Tsuto, T., Nakamura, K., Deguchi, E., Tokiwa, K., Iwai, N. J. Pediatr. Surg. (1996) [Pubmed]
  11. Isolation of decidual lymphocytes from chorionic villus samples: phenotypic analysis and growth in vitro. Haynes, M.K., Flanagan, M.T., Perussia, B., Jackson, L.G., Smith, J.B. Am. J. Reprod. Immunol. (1995) [Pubmed]
 
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