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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cd63  -  CD63 antigen

Mus musculus

Synonyms: C75951, ME491, Tspan30
 
 
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Disease relevance of Cd63

  • ME491 complementary DNA clones were then obtained by probing a melanoma complementary DNA library with the genomic subfragments [1].
  • Surface expression of CD63 antigen (AD1 antigen) in P815 mastocytoma cells by transfected IgE receptors [2].
 

High impact information on Cd63

  • Southern blot analysis revealed no amplification or rearrangement of the ME491 gene in the human melanoma cell lines tested, including both high and low expressors of this antigen [1].
  • The ME491 gene has been mapped to chromosome region 12p12----12q13 by somatic cell hybrid analysis and more narrowly localized to 12q12----12q14 by in situ hybridization [1].
  • Nucleotide sequence analysis of the cloned complementary DNA indicated that the ME491 antigen consists of 237 amino acids (Mr 25,475) with four transmembrane regions and three putative N-glycosylation sites [1].
  • The ME491 gene was molecularly cloned by means of DNA-mediated gene transfer followed by screening a lambda genomic library with human repetitive Alu sequences as a probe [1].
  • The cloned DNA, after transfection into mouse L-cells, generated a protein with characteristics that were indistinguishable in Western blot analysis from the ME491 antigen expressed by human melanoma cells [1].
 

Biological context of Cd63

  • Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome [3].
  • Of particular significance, the Ag is strikingly similar, with respect to both amino acid sequence (36% identity) and putative domain structure to ME491, a human stage-specific melanoma-associated Ag [4].
  • These results suggested that overexpression of ME491 antigen partially suppressed malignant phenotypes of H-ras-transformed NIH3T3 cells in athymic nude mice through co-operating with a factor(s) or mechanism(s) that exist in vivo but not in vitro [5].
 

Anatomical context of Cd63

References

  1. Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression. Hotta, H., Ross, A.H., Huebner, K., Isobe, M., Wendeborn, S., Chao, M.V., Ricciardi, R.P., Tsujimoto, Y., Croce, C.M., Koprowski, H. Cancer Res. (1988) [Pubmed]
  2. Surface expression of CD63 antigen (AD1 antigen) in P815 mastocytoma cells by transfected IgE receptors. Furuno, T., Teshima, R., Kitani, S., Sawada, J., Nakanishi, M. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  3. Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome. Gwynn, B., Eicher, E.M., Peters, L.L. Genomics (1996) [Pubmed]
  4. An immunogenic Mr 23,000 integral membrane protein of Schistosoma mansoni worms that closely resembles a human tumor-associated antigen. Wright, M.D., Henkle, K.J., Mitchell, G.F. J. Immunol. (1990) [Pubmed]
  5. Overexpression of the human melanoma-associated antigen ME491 partially suppresses in vivo malignant phenotypes of H-ras-transformed NIH3T3 cells in athymic nude mice. Hotta, H., Hara, I., Miyamoto, H., Homma, M. Melanoma Res. (1991) [Pubmed]
  6. Molecular cloning of the murine homologue of CD63/ME491 and detection of its strong expression in the kidney and activated macrophages. Miyamoto, H., Homma, M., Hotta, H. Biochim. Biophys. Acta (1994) [Pubmed]
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