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Gene Review

mnt  -  Mnt

Enterobacteria phage P22

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Disease relevance of mnt


High impact information on mnt

  • Four independent mutations change the same CAC codon in the mnt gene to CCT or CCC [3].
  • The arc and mnt genes of bacteriophage P22 encode small repressor proteins [4].
  • The isolation and characterization of streptozotocin (STZ)-induced mutations in the phage P22 mnt repressor gene is described [5].
  • Our results indicate that one of the repressors required for maintenance of lysogeny, the mnt gene product, may be partially responsible for this phenomenon [6].
  • This region includes the ant gene, which encodes the P22 antirepressor protein, and the mnt and arc genes, which encode proteins that negatively regulate antirepressor synthesis [7].

Chemical compound and disease context of mnt


Biological context of mnt

  • The arc and ant genes are transcribed rightward from the Pant promoter, while mnt is transcribed leftward from a promotor that may overlap Pant [7].
  • The majority of these mutations are A:T----G:C transitions that occur within six base pairs of the two 5'-GATC-3' sequences in the mnt gene [9].
  • We describe the isolation and genetic characterization of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced mutations in the phage P22 mnt repressor gene cloned in plasmid pBR322 [8].
  • The mnt gene may be a useful target for determining mutagenic specificity at the nucleotide level because forward mutations are easily isolated, the target size is small, and the DNA sequence changes of mutations can be determined rapidly [8].
  • Mutations in the mnt repressor gene or its operator on this plasmid, pPY98, confer a tetracycline resistance phenotype, whereas the wild-type plasmid confers tetracycline sensitivity [8].


  1. DNA specificity determinants of Escherichia coli tryptophan repressor binding. Bass, S., Sugiono, P., Arvidson, D.N., Gunsalus, R.P., Youderian, P. Genes Dev. (1987) [Pubmed]
  2. The superinfection exclusion gene (sieA) of bacteriophage P22: identification and overexpression of the gene and localization of the gene product. Hofer, B., Ruge, M., Dreiseikelmann, B. J. Bacteriol. (1995) [Pubmed]
  3. Changing the DNA-binding specificity of a repressor. Youderian, P., Vershon, A., Bouvier, S., Sauer, R.T., Susskind, M.M. Cell (1983) [Pubmed]
  4. The bacteriophage P22 arc and mnt repressors. Overproduction, purification, and properties. Vershon, A.K., Youderian, P., Susskind, M.M., Sauer, R.T. J. Biol. Chem. (1985) [Pubmed]
  5. Sequence specificity of streptozotocin-induced mutations. Mack, S.L., Fram, R.J., Marinus, M.G. Nucleic Acids Res. (1988) [Pubmed]
  6. Bacteriophage P22 tail protein gene expression. Adams, M.B., Brown, H.R., Casjens, S. J. Virol. (1985) [Pubmed]
  7. Primary structure of the immI immunity region of bacteriophage P22. Sauer, R.T., Krovatin, W., DeAnda, J., Youderian, P., Susskind, M.M. J. Mol. Biol. (1983) [Pubmed]
  8. Analysis of forward mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the bacteriophage P22 mnt repressor gene. Lucchesi, P., Carraway, M., Marinus, M.G. J. Bacteriol. (1986) [Pubmed]
  9. Spontaneous mutations occur near dam recognition sites in a dam- Escherichia coli host. Carraway, M., Youderian, P., Marinus, M.G. Genetics (1987) [Pubmed]
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