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Gene Review

Cry2  -  cryptochrome 2 (photolyase-like)

Mus musculus

Synonyms: AV006279, Cryptochrome-2, D130054K12Rik, Kiaa0658
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High impact information on Cry2

  • Mutant mice lacking either Cry1 or Cry2 have impaired light induction of the clock gene mPer1 and have abnormally short or long intrinsic periods, respectively [1].
  • Clock and Bmal1 are essential transcription factors that drive the expression of three period genes (Per1-3) and two cryptochrome genes (Cry1 and Cry2) [2].
  • A previous study showed that mice lacking the Cry2 gene had reduced sensitivity to acute light induction of the circadian gene mPer1 in the suprachiasmatic nucleus (SCN) and had an intrinsic period 1 hr longer than normal [3].
  • Here we investigated the expression of two clock genes (Per1, Cry2) and the level of phosphorylated (p) cyclic AMP response element binding protein (CREB) in retinae of melatonin-deficient (C57BL) with an intact retina and melatonin-proficient (C3H) mice with degenerated outer nuclear layer [4].
  • PURPOSE: The present study in a mouse model was undertaken to reveal the role of the circadian clock genes Cry1 and Cry2 in generation of 24-hour intraocular pressure (IOP) rhythm [5].

Biological context of Cry2


Other interactions of Cry2

  • Furthermore, Per1 and Cry2 oscillations in the SCN were phase advanced by 1 and 3 h, respectively, in hypocalorie- but not in normocalorie-fed mice [8].
  • Here, a decrease of positive feedback strength associated with mutating the Per2 gene is compensated by the Cry2-/- mutation that simultaneously decreases the negative feedback strength [9].
  • RNase protection assay and in situ hybridization revealed in both strains a rhythm in transcript levels for Per1 with a peak at zeitgeber time (ZT) 08, but not for Cry2 [4].


  1. Cryptochrome: the second photoactive pigment in the eye and its role in circadian photoreception. Sancar, A. Annu. Rev. Biochem. (2000) [Pubmed]
  2. Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Etchegaray, J.P., Lee, C., Wade, P.A., Reppert, S.M. Nature (2003) [Pubmed]
  3. Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Vitaterna, M.H., Selby, C.P., Todo, T., Niwa, H., Thompson, C., Fruechte, E.M., Hitomi, K., Thresher, R.J., Ishikawa, T., Miyazaki, J., Takahashi, J.S., Sancar, A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Clock gene expression in the retina of melatonin-proficient (C3H) and melatonin-deficient (C57BL) mice. Dinet, V., Ansari, N., Torres-Farfan, C., Korf, H.W. J. Pineal Res. (2007) [Pubmed]
  5. Circadian intraocular pressure rhythm is generated by clock genes. Maeda, A., Tsujiya, S., Higashide, T., Toida, K., Todo, T., Ueyama, T., Okamura, H., Sugiyama, K. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  6. Circadian genes in a blind subterranean mammal III: molecular cloning and circadian regulation of cryptochrome genes in the blind subterranean mole rat, Spalax ehrenbergi superspecies. Avivi, A., Oster, H., Joel, A., Beiles, A., Albrecht, U., Nevo, E. J. Biol. Rhythms (2004) [Pubmed]
  7. The involvement of Cry1 and Cry2 genes in the regulation of the circadian body temperature rhythm in mice. Nagashima, K., Matsue, K., Konishi, M., Iidaka, C., Miyazaki, K., Ishida, N., Kanosue, K. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
  8. Feeding cues alter clock gene oscillations and photic responses in the suprachiasmatic nuclei of mice exposed to a light/dark cycle. Mendoza, J., Graff, C., Dardente, H., Pevet, P., Challet, E. J. Neurosci. (2005) [Pubmed]
  9. Modeling feedback loops of the Mammalian circadian oscillator. Becker-Weimann, S., Wolf, J., Herzel, H., Kramer, A. Biophys. J. (2004) [Pubmed]
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