Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

SPATA4 - spermatogenesis associated 4

Homo sapiens

Synonyms: SPEF1B, Spermatogenesis-associated protein 4, TSARG2, Testis and spermatogenesis cell-related protein 2, Testis spermatocyte apoptosis-related gene 2 protein

Liu, S.F. et al., Liu, S.F. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SPATA4

A novel human gene full-length cDNA sequence-TSARG2 was identified from a human testis cDNA library using the SRG2 gene (GenBank Accession No. ), which was significantly up-regulated in cryptorchidism, as an electronic probe [1].

High impact information on SPATA4

TSARG2 can accelerate MCF7 cells to traverse the S-phase and enter the G2-phase compared with the control without transfection of TSARG2, which suggested that this gene plays an important role in the development of cryptorchid testis and is a testis-specific apoptosis candidate oncogene [1].
Furthermore, results of in situ hybridization assay confirmed that TSARG2 was expressed in seminiferous tubules, more precisely in spermatogonia and spermatocyte [1].
In conclusion, this study proves the conservation of SPATA4 in mammalian animals and predicts its important role in spermatogenesis [2].

Anatomical context of SPATA4

Multi-tissue RT-PCR results show that the SPATA4 gene is expressed specifically in the testis only [2].

Analytical, diagnostic and therapeutic context of SPATA4

According to the RT-PCR results, no expression of SPATA4 is detected until the rat is 30 d old after birth [2].
Northern blot analysis revealed that 1.7 kb TSARG2 transcript was detected selectively in human testis [1].

References

Cloning of a full-length cDNA of human testis-specific spermatogenic cell apoptosis inhibitor TSARG2 as a candidate oncogene. Liu, S.F., Lu, G.X., Liu, G., Xing, X.W., Li, L.Y., Wang, Z. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
Cloning and characterization of testis-specific spermatogenesis associated gene homologous to human SPATA4 in rat. Liu, S.F., He, S., Liu, B.W., Zhao, Y., Wang, Z. Biol. Pharm. Bull. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

SPATA4	Bos taurus
SPATA4	Canis lupus familiaris
spata4	Danio rerio
SPATA4	Gallus gallus
SPATA4	Macaca mulatta
Spata4	Mus musculus
SPATA4	Pan troglodytes
Spata4	Rattus norvegicus
spata4	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.